CAS: 59-40-5; Sulfaquinoxaline

相似化合物

59-40-5 97919-22-7 166271-34-7

上下游产品

CAS号6632-67-3 Acetamide,N-[4-... | CAS号5424-05-5 2-氨基喹喔啉 | CAS号490-59-5 Alloxazine | CAS号85414-82-0 2-Quinoxalineca... | CAS号121-60-8 对乙酰氨基苯磺酰氯 | CAS号1448-87-9 2-氯喹恶啉 | CAS号63-74-1 磺胺 | CAS号681235-15-4 4-isothi°Cyanat...

对乙酰胺基苯磺酰氯置于吡啶,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 磺胺喹噁啉
参考文献:稠合杂环mlkl抑制剂的设计,合成及其抗坏死性凋亡活性
标题:稠合杂环mlkl抑制剂的设计,合成及其抗坏死性凋亡活性
摘要:坏死性凋亡是程序性细胞死亡 (Pcd) 的一种重要形式,由死亡受体介导且独立于 Caspase 蛋白水解酶.混合谱系激酶结构域样(mlkl)是坏死性凋亡的最终效应器,在坏死性凋亡的执行中发挥着不可替代的作用.然而,Mlkl抑制剂的研究还处于起步阶段. Necrosulfonamide (Nsa) 是一种早期发现的共价 Mlkl 抑制剂,具有中等抗坏死性凋亡活性和尚未广泛披露的构效关系 (Sar).在本研究中,在保留共价基序的情况下,我们旨在通过引入末端稠合杂环并同时揭示部分的sar来提高活性.结果,化合物 和 通过与 Mlkl 共价结合而在类似物中表现出最佳的抗坏死性凋亡活性(ec = 148.4 和 595.9 Nm).特区政府的成立也是为了指导该领域的进一步结构优化.
DOI:10.1016/j.Bmc.2024.117659

专利信息

专利号:US-9439423-B2
优先权日:2007-10-29
标 题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
发明人：KAWANO FUMI; HIRAZAWA NORITAKA
权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
摘要:An antiparasitic agent for fish includes an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is disclosed. Sulfonamide is disclosed as suitable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist are disclosed as suitable inhibitors of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is effective against fish parasites belonging to the ciliate group.

专利号:US-9265777-B2
优先权日:2009-04-27
标题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
发明人：KAWANO FUMI; HIRAZAWA NORITAKA
权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
摘要:A method of controlling proliferation of fish parasites comprising the administration of 1 to 50 mg/kg fish body weight/day of an inhibitor of folate synthesis and/or an inhibitor of folate activation to fish continuously for 1 to 2 weeks. Using a combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.

专利号:US-2023398101-A1
优先权日:2022-06-09
标题 :Co-agents as Therapy Against Anaerobic Pathogens
发明人：PACE JOHN LEE; HARTSELL THERESA LYNN
权利人:FLEURIR ABX LLC
摘要:Co-agent combinations and/or formulations herein unexpectedly display significantly better antimicrobial activity (e.g., more efficacy and/or more potency) against anaerobic pathogens not previously considered targets. With three or more co-agents, selected from a group of a fosfomycin, a diaminopyridine, a sulfonamide, a beta lactam antibacterial, a bacterial beta-lactamase inhibitor, a bacterial fosfomycin-modifying enzyme, and a bacterial peptidoglycan synthesis inhibitor, the therapeutic potential of the three or more co-agents is expanded by targeting a broader spectrum of pathogens. Co-agents, by unexpected synergistic action in an anaerobic environment, are now active and efficacious against difficult to treat pathogenic anaerobes (including anaerobes that cannot utilize oxygen and/or reside in an anaerobic environment, some being inhibited by oxygen), as well as pathogens considered resistant or intolerant to at least one of the co-agents when used singly in an anaerobic environment. Some co-agent combinations and/or formulations contain one or more existing antibiotic agents being repurposed for utility against difficult to treat anaerobic pathogens.

专利号:TW-I429397-B
优先权日:2009-04-27
标题:Use of a composition containing a folic acid synthesis inhibitor and/or a folic acid activation inhibitor

专利号:CN-117964549-A
优先权日:2024-01-05
标题 :Synthesis and antibacterial application of novel thymol derivative containing piperidine and sulfonamide active fragments