CAS: 69267-75-0; 2-Bromo-1-Cyclopropylethanone

相似化合物

21994-20-7 658076-48-3 76714-45-9

上下游产品

CAS号1083274-67-2 4-环丙基-2-噻唑甲酸

环丙甲基酮置于n-溴代丁二酰亚胺(Nbs),三氟甲磺酸三甲基硅酯体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,以33%的收率获得产物2-溴-1-环丙基乙酮
参考文献:Mniii 引发的 β-酮羰基化合物氧化的机理和范围:呋喃合成
标题:Mniii 引发的 β-酮羰基化合物氧化的机理和范围:呋喃合成
摘要:除非由 β-酮羰基化合物产生的 Mniii 碳自由基顺利地与烯烃进行分子内加成,否则它会捕获反应介质中的分子氧以产生过氧自由基,该自由基与相邻的羰基反应形成 1,2-二氧杂环丁烷.1,2-二氧杂环丁烷的热分解完成氧化以产生α-氧代酯.这种氧化在 50 oc 下在有氧条件下似乎是普遍的,并且可以在 Acoh 中通过超声波照射催化 Mniii.因此,基于 Mniii 引发的具有合适 α-烯丙基取代的 β-酮羰基化合物的多米诺氧化反应,开发了一种用于不同取代的呋喃的新合成方法.
DOI:10.1002/ejoc.201201194

专利信息

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:US-6271392-B1
优先权日:1994-10-07
标题:Intermediates useful for the synthesis of 1-arylpyrrole pesticides
发明人：CHENE ALAIN; HUBER SCOT KEVIN
权利人:RHONE POULENC INC
摘要:The present invention pertains to novel 3-substituted-4-thiopyrrole intermediates for the preparation of 1-arylpyrrole compounds that are useful for the control of insects, acarids and nematodes. n The compounds, including their isomers, e.g., diastereomers and optical isomers, are compounds of a general formula (I) n wherein the structural variables are as defined in the description.

专利号:RU-2378252-C2
优先权日:2004-04-02
标题 :Novel method for synthesis of intermediate compounds, used in synthesis of vitamin d analogues

专利号:WO-2018151830-A1
优先权日:2017-02-17
标 题:Pyridinyl based apoptosis signal-regulation kinase inhibitors
发明人：JIN BOHAN; DONG QING; HUNG GENE
权利人:FRONTHERA U S PHARMACEUTICALS LLC
摘要:Apoptosis signal-regulating kinase 1 (ASK1) activation and signaling have been reported to play an important role in a broad range of diseases including neurodegenerative, cardiovascular, inflammatory, autoimmunity and metabolic disorders. Disclosed herein is the synthesis of pyridinyl derived therapeutic agents that function as inhibitors of ASK 1 as well as their pharmaceutical compositions and methods of use.

专利号:JP-H08193063-A
优先权日:1994-10-07
标题 :Novel intermediates useful in the synthesis of 1-arylpyrrole pesticides

专利号:JP-2007530602-A
优先权日:2004-04-02
标题:Novel process for the production of intermediates useful for the synthesis of vitamin D analogues