CAS: 72804-96-7; O-Diphenylphosphinylhydroxylamine

上下游产品

N-hydroxy-P,P-diphenylphosphinic amide sodium methylate Diphenylphosphinic chloride chlorophosphoric acid diphenyl esterN-acetyl-O-(diphenylphosphinyl)hydroxylamine 3-[[1-[3-(Trifluoromethyl)phenyl]hydrazino]carbonyl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester Methyl 2-[[-1-[4-(trifluoromethyl)phenyl]hydrazino]carbonyl]-2,3-dihydro-7-(trifluoromethyl)[1]benzopyrano[4,3-c]pyrazole-3a (4H)-carboxylate 6-methyl-2-(trifluoromethyl)-8-((3-trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-b]pyridazine

二苯基次膦酰氯置于羟胺体系中,用 苯 作为反应溶剂,化学反应生成 二苯基膦酰羟胺
参考文献:O-(二苯基膦基)羟胺:制备及一些典型的化学反应
标题:O-(二苯基膦基)羟胺:制备及一些典型的化学反应
摘要:羟胺与二苯次膦酰氯(1)在苯(或二恶烷水溶液)中反应反应生成o-(二苯次膦酰基)羟胺(3),而不是n-次膦酰基化合物(2).二p甲苯基-,双-P-Methoxphenyl-,和苯基-P-Methoxphenyl次膦氯化物类似地通过羟胺的氧气攻击.膦酰基羟胺的结构可以从它们的化学反应中推论出来.特别地,它们与丙酮缩合,得到与从次膦酰氯和丙酮肟获得的那些相同的次膦酰基丙酮肟(8).就像ø-Sulphonylhydroxylamines,ö-(二苯基膦基)羟基胺分别与三苯基膦和二甲基硫醚形成氨基phosph盐和氨基s盐.
DOI:10.1039/p19810003284

专利信息

专利号:US-10640508-B2
优先权日:2017-10-13
标 题 :Diazene directed modular synthesis of compounds with quaternary carbon centers
发明人：MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are directed to the preparation of compounds of Formula (I), or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, from compounds of Formula (II): n nwherein R 1 -R 5 and q are as defined independently for each occurrence herein. A wide variety of compounds can be accessed in this manner, including oligocyclotryptamines, where the stereochemistry of each subunit is beneficially secured before fragment coupling.

专利号:US-2017342077-A1
优先权日:2016-05-24
标题 :Diazene directed modular synthesis of compounds with quaternary carbon centers
发明人：MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
权利人:MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
摘要:Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are directed to the preparation of compounds of Formula (I), or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, from compounds of Formula (II): n n n n n n n n n n wherein R 1 -R 5 and q are as defined independently for each occurrence herein. A wide variety of compounds can be accessed in this manner, including oligocyclotryptamines, where the stereochemistry of each subunit is beneficially secured before fragment coupling.

专利号:WO-2025128873-A1
优先权日:2023-12-12
标题:Heterocyclic pyridinone compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2021085684-A1
优先权日:2016-07-06
标 题:Pde9 inhibitors for treatment of peripheral diseases
发明人：SVENSTRUP NIELS; PARACHIKOVA ANNA I; MCARTHUR JAMES
权利人:IMARA INC
摘要:The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyperplasia, beta thalassemia, and sickle cell disease.