CAS: 99353-00-1; (R)-3-(3,4-Dihydroxyphenyl)-1-Methoxy-1-Oxopropan-2-Yl (E)-3-(3,4-Dihydroxyphenyl)Acrylate

上下游产品

(E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid (R)-2-(3,4-bis-benzyloxy-phenyl)-1-methoxycarbonyl-ethyl ester methanol (R)-(+)-rosmarinic acid (+)-(S)-methyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate51H38F12O8C51H38F12O8 (R)-1-(allyloxy)-3-(3,4-bis(benzyloxy)phenyl)-1-oxopropan-2-yl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate 23H22O5C23H22O5 allyl (R)-3-(3,4-bis(benzyloxy)phenyl)-2-hydroxypropanoate

(R)-Methyl 3-(3,4-Bis(Benzyloxy)Phenyl)-2-Hydroxypropanoate置于4-二甲氨基吡啶,三氯化硼体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 迷迭香酸甲酯
参考文献:Synthese Der Enantiomeren (+)-Und (−)-Rosmarinsäuremethylester
标题:Synthese Der Enantiomeren (+)-Und (−)-Rosmarinsäuremethylester
摘要:
DOI:10.1007/pl00010154

专利信息

专利号:US-2024084338-A1
优先权日:2022-11-22
标 题 :Recombinant Escherichia coli for producing rosmarinic acid and its application thereof
发明人：ZHOU JINGWEN; CHEN JIAN; WANG LIAN; ZENG WEIZHU; YU SHIQIN
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses a recombinant Escherichia coli for producing rosmarinic acid and application thereof, belonging to the technical fields of genetic engineering and bioengineering. In the present disclosure, FjTA derived from Flavobacterium johnsoniae, endogenous hpaBC derived from E. coli, CbRAS derived from Coleus blumei, HPPR derived from Coleus scutellarioides, and Pc4CL1 derived from Petroselinum crispum are heterologously expressed in E. coli, realizing synthesis of rosmarinic acid. TcTAL derived from Trichosporon cutaneum and tyrC for removing feedback inhibition are introduced, further increasing synthesis throughput of caffeic acid, and PmLAAD derived from Proteus myxofaciens is heterologously expressed, realizing redistribution of L-DOPA. An endogenous gene menl is knocked out, improving the content and stability of a rosmarinic acid precursor. The recombinant strain constructed in the present disclosure can produce rosmarinic acid by fermentation at a yield of up to 511.2 mg/L, providing a new method for industrial production of rosmarinic acid.