CAS: 105191-13-7; Ethyl 5-Cyanoindole-2-Carboxylate

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CAS号16732-70-0 5-溴吲哚-2-羧酸乙酯 | CAS号544-92-3 氰化亚铜 | CAS号169463-44-9 5-氰基-1H-吲哚-2-羧酸 | CAS号64-17-5 乙醇 | CAS号96784-54-2 3-甲基-4-硝基苯甲腈 | CAS号169463-44-9 5-氰基-1H-吲哚-2-羧酸 | CAS号15861-24-2 5-氰基吲哚

在 溶剂黄146,锌体系中,化学反应生成5-氰基-1H-吲哚-2-羧酸乙酯
参考文献:Design,Synthesis And Structure-activity Relationships Of Benzoxazinone-Based Factor Xa Inhibitors
标题:Design,Synthesis And Structure-activity Relationships Of Benzoxazinone-Based Factor Xa Inhibitors
摘要:A Series Of Benzoxazinone Derivatives Was Designed And Synthesized As Factor Xa Inhibitors. We Demonstrated That The Naphthyl Moiety In The Aniline-Based Compounds I And 2 Can Be Replaced With Benzene-Fused Heterobicycles And Biaryls To Give Factor Xa Inhibitors With Improved Trypsin Selectivity. The P4 Modifications Lead To Monoamidines Which Are Moderately Active. The Benzoxazinones 41-45 Are Potent Against Factor Xa,Retain The Improved Trypsin Selectivity Of The Corresponding Aniline-Based Compounds,And Show Strong Antithrombotic Effect Dose Responsively. (C) 2002 Published By Elsevier Science Ltd.
Doi:10.1016/s0960-894X(02)00927-7