CAS: 1071-73-4; 5-Hydroxypentan-2-One

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N-(2-((2-Methyltetrahydrofuran-2-yl)Oxy)Ethyl)Acrylamide置于4-甲氧基苯酚体系中,用 Aq. Acetate Buffer 用作溶剂,化学反应生成5-羟基-2-戊酮
参考文献:用环状缩醛重复单元调节瞬态热敏聚丙烯酰胺的酸敏感性
标题:用环状缩醛重复单元调节瞬态热敏聚丙烯酰胺的酸敏感性
摘要:摘要 融合热响应性和刺激降解性聚合物的特性,可以得到所谓的瞬态热响应性聚合物,该瞬态热响应性聚合物可以在生物医学领域内用于可注射凝胶,纳米颗粒等的设计.在这些聚合物中,仅报道了有限数量的聚合物,其在温和的酸性条件下表现出选择性降解.但是,需要扩展瞬态热响应性聚合物库以扩展生物材料工具箱以适应特定需求.通过用3,4-二氢-2 H进行四氢吡喃基化或-呋喃基化反应对2-羟乙基丙烯酰胺(heam)进行修饰来开发三种单体-吡喃(dhp),2,3-二氢呋喃(dhf)或2,3-二氢-5-甲基呋喃(medhf).缩醛或缩酮键的存在为单体提供了数分钟至数天的ph依赖性水解行为.Raft聚合可构建具有温度响应行为和ph依赖性水解的均聚物,而该单体受单体重复单元的性质影响很大.
Doi:10.1007/s11426-019-9705-4

专利信息

专利号:US-2024092821-A1
优先权日:2020-03-31
标题:Synthesis of oligonucleotides and related compounds
发明人：ZHONG MINGHONG; JIN YI; GALA DINESH; PRHAVC MARIJA
权利人:JANSSEN BIOPHARMA INC
摘要:Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide subunit on a cleavable support having an azidomethyl moiety and a nucleoside phosphoramidite or an oligonucleotide phosphoramidite, capping, oxidation/thiolation and deblocking; followed by orthogonal cleavage of the azidomethyl support while keeping all other protecting groups intact. The method can be used in combination with a support moiety for either solid phase or liquid phase oligo synthesis. The soluble support facilitates homogeneous reactions and efficient separations by simple precipitation. The methods also provide novel intermediates useful in the synthesis of oligonucleotide conjugates.

专利号:US-5788950-A
优先权日:1994-08-03
标 题 :Method for the synthesis of mixed metal oxide powders
发明人：IMAMURA KUNIO; DIGREGORIO JOHN F; SMITH DOUGLAS M; IZAWA HIROZUMI; YAMAGUCHI TETSUHIKO
权利人:SHOWA DENKO KK
摘要:A technique to synthesize complex oxide ceramic powders which offers advantages of both the coprecipitation and sol-gel routes while doing away with the disadvantages is disclosed. Namely, the ability to achieve chemical homogeneity and crystallite size on the namometer length scale at a nonprohibitive cost is provided by the disclosed method. In one embodiment of the invention, a method for the synthesis of a mixed metal oxide powder is provided including (a) combining a liquid absorbent resin with at least one solution selected from the group consisting of solutions containing at least one organo-metallic compound and solutions containing at least one metallic salt compound, such that at least two metals are present in the liquid absorbent resin after the combining is completed; (b) after the combining, allowing the liquid absorbent resin to swell and gel and thereby form a swollen gel; (c) preparing a precursor material by changing at least one of the pH and temperature of the swollen gel; (d) pyrolyzing the precursor material to form a pyrolyzed precursor material; and (e) calcining the pyrolyzed precursor material to form a mixed metal oxide powder.

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:US-5338686-A
优先权日:1992-04-29
标 题:Method for measuring in vivo synthesis of biopolymers
发明人：HELLERSTEIN MARC K
权利人:HELLERSTEIN MARC K
摘要:A method for determining the mass isotope enrichment of a subunit from which a biopolymer is formed, and the rates of synthesis and decay of the biopolymer. The mass isotope enrichment of the subunit is determined by comparing the mass isotopomer distribution of the biopolymer after administration of a mass isotopically labeled subunit, with the expected frequencies of the different mass isotopomers produced from a given subunit mass isotope enrichment. To determine the synthesis rate of the biopolymer, the expected frequency of a selected biopolymer mass isotopomer, calculated from the subunit isotope enrichment, is compared with the actual frequency of that biopolymer mass isotopomer. To determine biopolymer decay, the decay rate of high mass isotopomers of the biopolymer is determined.

专利号:US-4978744-A
优先权日:1989-01-27
标题:Synthesis of dolastatin 10
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:A complicated but extremely important scheme of synthesis has been developed for synthesizing, dolaisoleuine, dolaproine, dolaphenine and dolavaline from readily available starting materials such as Z-(S,S)isoleucine, S-phenylalaline, S-phenylalaninol, S-prolinol, S-mandelate, and S-valine. The requisite amino acids have been combined using several peptide coupling procedures to create pharmaceutically pure dolastatin 10.

专利号:US-7135565-B2
优先权日:2000-07-28
标题 :Synthesis of polynucleotides using combined oxidation/deprotection chemistry
发明人：DELLINGER DOUGLAS J; PERBOST MICHAEL G M; CARUTHERS MARVIN H; BETLEY JASON R
权利人:UNIV COLORADO
摘要:A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the second nucleoside having a hydroxyl protecting group that is a non-carbonate protecting group. The product of the foregoing step is exposed to a composition which both oxidizes the formed phosphite to a phosphate and deprotects the protected hydroxyl of the coupled nucleoside. The method has particular application to fabricating an addressable array of polynucleotides on a substrate which carries substrate bound moieties each with a hydroxyl group.