CAS: 177966-63-1; Fmoc-D-Phe(4-No2)-Oh

相似化合物

95753-55-2 207591-86-4 2922-40-9

上下游产品

(fluorenylmethoxy)carbonyl chloride 4-nitro-3-phenyl-L-alanine N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide L-phenylalanine2)-D-Asp[*]-NH2H-Tyr-D-Orn[*]-Phe(p-NO2)-D-Asp[*]-NH2

(R)-Tert-Butyl 2-(((9H-Fluoren-9-yl)Methoxy)Carbonylamino)-3-(4-Nitrophenyl)Propanoate置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,以100%的收率获得fmoc-D-对硝基苯丙氨酸
参考文献:含有修饰的d-苯丙氨酸残基的不对称短杆菌肽s类似物的合成和生物学评估
标题:含有修饰的d-苯丙氨酸残基的不对称短杆菌肽s类似物的合成和生物学评估
摘要:报道了具有修饰的d-苯丙氨酸残基的阳离子抗菌肽短杆菌肽s的新类似物的合成,它们对几种革兰氏阳性和阴性菌株的抗菌性能以及其溶血活性.
Doi:10.1016/j.Bmc.2009.07.042

专利信息

专利号:US-12098218-B2
优先权日:2015-12-17
标题 :Process for the manufacture of degarelix and its intermediates
发明人：RICCI ANTONIO; ZANON JACOPO; CABRI WALTER; GURYANOV IVAN; ORLANDIN ANDREA; BIONDI BARBARA; FORMAGGIO FERNANDO; VISENTINI DARIO
权利人:FRESENIUS KABI IPSUM S R L
摘要:The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.