2-苄氧基-6-甲基吡啶置于n,N-二甲基甲酰胺,三氯氧磷体系中,化学反应 40.0H,以67%的收率获得2-甲基-6-氯吡啶 参考文献:Lai,Long-Li; Lin,Pen-Yuan; Wang,Jy-Shih,Journal Of Chemical Research-Part S,1996,# 4,P. 194-195 标题:Lai,Long-Li; Lin,Pen-Yuan; Wang,Jy-Shih,Journal Of Chemical Research-Part S,1996,# 4,P. 194-195
专利号:US-9676783-B2 优先权日:2008-10-22 标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds 发明人:HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN 权利人:ARRAY BIOPHARMA INC 摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
专利号:US-8853410-B2 优先权日:2009-04-30 标 题:Process for preparing substituted isoxazoline compounds and their precursors 发明人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN 权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE 摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.
专利号:WO-2023114200-A2 优先权日:2021-12-14 标题 :Methods for the synthesis of complement factor d inhibitors and intermediates thereof
专利号:WO-2009073246-A1 优先权日:2007-12-06 标 题 :Method for the synthesis of iridium (iii) complexes with sterically demanding ligands
专利号:US-10407676-B2 优先权日:2014-12-09 标题 :High efficiency, small volume nucleic acid synthesis 发明人:POEHMERER THOMAS; KUHN PHILLIP; NOTKA FRANK; ZEIDLER ANDREAS; HEIL KORBINIAN; TREFZER AXEL; FONNUM GEIR; KATZEN FEDERICO; ANDERSSON KRISTIAN 权利人:LIFE TECHNOLOGIES CORP; THERMO FISHER SCIENT GENEART GMBH; LIFE TECH AS 摘要:The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
专利号:US-4369322-A 优先权日:1978-12-15 标 题 :Process for the production of substituted acetonitriles 发明人:SCHALKE PETER; KLEEMANN AXEL 权利人:DEGUSSA 摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.
[参考文献]: V Arjunan, Et Al. A Comparative Study On Vibrational, Conformational And Electronic Structure Of 2-Chloro-4-Methyl-3-Nitropyridine And 2-Chloro-6-Methylpyridine. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jun 15:92:305-17.
合成参考文献
摘要:Gagnon, A.; Benoit, E.; Le Roch, A., Science of Synthesis Knowledge Updates, (2018) 4, 81. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 400. 摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 22. 摘要:Ouali, A.; Taillefer, M., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 103. 摘要:Seki, M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 132.