CAS: 2620-62-4; (2R,3R,4S,5R)-2-(6-(Dimethylamino)-9H-Purin-9-yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

上下游产品

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(dimethylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate dimethyl amine (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate N6,N6,S-trimethyl-2-thio-isoguanosineN6,N6,S-trimethyl-2-thio-isoguanosineO2',O3'-((R)-benzylidene)-N6,N6-dimethyl-adenosineO2',O3'-((R)-benzylidene)-N6,N6-dimethyl-adenosine 6,N6'-dimethyladenosine2',3'-O-isopropylidene-N6,N6'-dimethyladenosine 6,N6-Dimethyl-5'-O-trityladenosineN6,N6-Dimethyl-5'-O-trityladenosine 2',3',5'-tri-O-benzyl-N,N-dimethyladenosine

2',3',5'-三乙酰腺苷置于吡啶体系中,用 水 用作溶剂,化学反应 20.67H,反应生成N6,N6-二甲基腺苷
参考文献:Miles,Robert W.; Samano,Vicente; Robins,Morris J.,Journal Of The American Chemical Society,1995,Vol. 117,# 22,P. 5951-5957
标题:Miles,Robert W.; Samano,Vicente; Robins,Morris J.,Journal Of The American Chemical Society,1995,Vol. 117,# 22,P. 5951-5957

专利信息

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:WO-2025217610-A1
优先权日:2024-04-12
标题:Systems and methods for enzymatic oligonucleotide synthesis
发明人：ENTWISTLE DAVID; GAUNTLETT DEREK; MILLER MICHAEL; REEVES RYAN; WATTS DAVID
权利人:CODEXIS INC
摘要:The present invention provides for methods and systems for template-free synthesis of an oligonucleotide, and methods of using the systems as disclosed herein for template-free synthesis of an oligonucleotide.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

专利号:US-2025207163-A1
优先权日:2022-03-25
标 题:Methods and apparatus for synthesizing nucleic acids
发明人：HOPKINS PATRYCJA A; SHAHSAVARI SHAHIEN; BEGOYAN VAGARSHAK; NJUMA OLIVE J; DEBENHAM HOLLY S; EFCAVITCH J WILLIAM; ALBIZATI KIM F
权利人:MOLECULAR ASSEMBLIES INC
摘要:Methods for the synthesis of polynucleotides using polymerases nucleotide analogs with labile terminator groups that allow stepwise addition of nucleotides are described. These nucleotide analogs may have a modification on 3′, 2′, or 3′-2′-bridged hydroxyl groups or on nucleobase moieties and can be used in the synthesis of natural or modified polynucleotides suitable for use in biological systems. The labile terminator groups are removed under mild conditions or by enzymes. They are accepted as substrates by polymerases. The synthesis may be carried out on a surface.