CAS: 344327-11-3; 4-Cyano-7-Azaindole

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728034-12-6 479553-01-0 824-24-8

上下游产品

CAS号557-21-1 氰化锌 | CAS号55052-28-3 4-氯-7-氮杂吲哚 | CAS号319474-34-5 4-碘-7-氮杂吲哚 | CAS号271-63-6 7-氮杂吲哚 | CAS号936549-95-0 7-N-杂吲哚-3-甲醇 | CAS号479553-01-0 7-氮杂吲哚-4-羧酸 | CAS号728034-12-6 7-氮杂吲哚-4-甲醛 | CAS号1268390-67-5 4-(chloromethyl... | CAS号1261588-72-0 1H-吡咯并[2,3-b]吡啶... | CAS号888498-07-5 4-氨甲基-7-氮杂吲哚

7-氮杂吲哚置于二苯基膦基二茂铁,Tris-(Dibenzylideneacetone)Dipalladium(0) 锌,三氯氧磷体系中,用 乙二醇二甲醚,正庚烷,异丁酰胺 作为反应溶剂,化学反应 5.0H,反应生成 4-氰基-7-氮杂吲哚
参考文献: 5,6-Bicyclic Heteroaryl-Containing Urea Compounds As Kinase Inhibitors[fr] Composés D'Urée Contenant Un Groupe Hétéroaryle 5,6-Bicyclique
标题: 5,6-Bicyclic Heteroaryl-Containing Urea Compounds As Kinase Inhibitors[fr] Composés D'Urée Contenant Un Groupe Hétéroaryle 5,6-Bicyclique
摘要:本发明提供了formula I或ii中含有5,6-双环杂芳基脲化合物,并将其用于治疗由蛋白激酶介导的疾病,如vegfr2,C-Met,Pdgfrβ,C-Kit,Csflr或epha2.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.