CAS: 3900-93-4; 2-Cyclopentyl-2-Phenylacetic Acid

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CAS号103-82-2 苯乙酸 | CAS号1556-18-9 碘环戊烷 | CAS号3753-59-1 rac-cyclopentyl... | CAS号930-28-9 氯代环戊烷 | CAS号140-29-4 苯乙腈 | CAS号110480-94-9 rac-(cyclopenty... | CAS号5422-88-8 苯基环戊基酮 | CAS号7037-44-7 Cyclopentyl(phe...

碳酸甲丙酯 以 水 作为反应溶剂,化学反应生成 α-苯基环戊基乙酸
参考文献:软药品.3.一类新的抗胆碱能药.
标题:软药品.3.一类新的抗胆碱能药.
摘要:设计并合成了一类新的抗毒蕈碱药物.这些化合物是"软"季铵酯,其中只有一个碳原子将酯氧和季头分开.当衍生自受阻的"伞"酸时,该化合物是有效的抗胆碱能药,而当衍生自简单脂肪酸时,这些化合物是胆碱能药.与阿托品相比,更有效的抗胆碱能药具有高达10倍的乙酰胆碱拮抗剂活性,但作用时间却短得多.该化合物水解裂解,同时破坏四级头.该化合物有望作为选择性的局部药物,特别是作为内分泌出汗的抑制剂.
DOI:10.1021/jm00179A002

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.