CAS: 5202-85-7; 2-Amino-5-Chlorobenzamide

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5-氯靛红置于n-甲基吗啉,1-羟基苯并三唑,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,Sodium Hydroxide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 1.0H,反应生成 2-氨基-5-氯苯甲酰胺
参考文献:发现 4-羟基喹唑啉衍生物作为小分子 Bet/parp1 抑制剂可诱导缺陷同源重组并导致三阴性乳腺癌治疗的合成致死率
标题:发现 4-羟基喹唑啉衍生物作为小分子 Bet/parp1 抑制剂可诱导缺陷同源重组并导致三阴性乳腺癌治疗的合成致死率
摘要:聚(adp-核糖)聚合酶(parp)抑制剂的有效效力和抗性限制了它们的应用.在这里,基于先前发现的含溴结构域蛋白 4 (Brd4) 和 Parp1 之间潜在的合成致死效应,我们利用一种模拟乳腺癌易感基因 (Brca) 突变的影响的新范例来触发合成致死的可能性. . 因此,本研究描述了对 Brd4 和 Parp1 具有高选择性的化合物bp44 .幸运的是,Bp44抑制三阴性乳腺癌 (Tnbc) 中的同源重组并触发合成致死性,从而导致细胞周期停滞和 Dna 损伤.综上所述,我们在前期研究的基础上对brd4-Parp1抑制剂进行了优化,我们期待它在未来成为治疗tnbc的候选药物.该策略旨在扩大 Parpi置于brca 能力的 Tnbc 中的使用,以创新方法解决未满足的肿瘤学需求.
DOI:10.1021/acs.Jmedchem.2C00135

专利信息

专利号:CN-102911126-A
优先权日:2012-11-20
标题 :Synthesis of 2-arylquinazolinones from benzyl halides and anthranilamides

专利号:SU-1739849-A3
优先权日:1987-08-03
标题 :Method for synthesis of benzamide derivatives or their pharmacologically acceptable salts

专利号:CN-103613550-A
优先权日:2013-11-29
标题 :Green Synthesis of 4(3H)-Quinazolinone

专利号:US-4772618-A
优先权日:1985-08-06
标题:Benzamides
发明人：VEGA-NOVEROLA ARMANDO; PRIETO-SOTO JOSE M; PUJOL-NOGUERA FERNANDO; MORAGUES-MAURI JACINTO; SPICKETT ROBERT G W
权利人:FORDONAL SA
摘要:Substituted benzamides of the general formula I I in which: R represents an alkoxy, alkenyloxy or alkynyloxy group containing up to 7 carbon atoms in the group, R1 is hydrogen or a NR4R5, or NR6COR7 group, where R4, R5 and R6, which may be the same or different, is each hydrogen or an alkyl group and R7 is an alkyl or trifluoromethyl group, R2 is hydrogen, halogen, or a nitro, or sulphamoyl group, R3 represents hydrogen or a methyl or methoxy group, X represents a hydrocarbon chain containing 1 to 4 carbon atoms, one of which may optionally be replaced by an oxygen atom, Y represents a non-aromatic cyclic ether or a non-aromatic cyclic thioether group and pharmaceutically acceptable salts thereof are useful in the treatment of gastro-intestinal disorders. Various methods of synthesis are described including synthesis via novel amines of the formula IIIa which are themselves obtained by reduction of the corresponding oximes.

专利号:CN-107367495-A
优先权日:2017-07-19
标 题 :A kind of precipitation type alkaline phosphatase fluorescent probe and its synthesis method and application

专利号:CN-104557738-A
优先权日:2014-12-23
标 题 :A kind of green synthesis method of 4(3H)-quinazolinone