CAS: 58-97-9; ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methyl Dihydrogen Phosphate

相似化合物

3387-36-8 22256-98-0 64426-16-0

上下游产品

2',3'-O-isopropylideneuridine orotic acid (R)-2',3'-O-benzylideneuridine 5-phosphoribosyl-1-pyrophosphate5-Brom-uridin-5'-phosphat uridine 3',5'-cyclic monophosphate UDP UTP

尿嘧啶核苷 反应生成 尿苷5-单磷酸
参考文献:用于碳水化合物和核苷选择性单磷酸化的固相试剂
标题:用于碳水化合物和核苷选择性单磷酸化的固相试剂
摘要:使对乙酰氧基苄醇的两类与氨基甲基聚苯乙烯树脂结合的连接基与2-氰基乙基n,N-二异丙基氯代亚磷酰胺反应以产生相应的与聚合物结合的磷酸化试剂.在1 H-四唑存在下,它们与许多未保护的核苷和碳水化合物反应.用叔丁基氢过氧化物氧化,然后用1,8-二氮杂双环[5.4.0]十一碳-7-烯除去氰基乙氧基,得到相应的聚合物结合的磷酸二酯.p的酸性裂解-乙酰氧基苄醇连接基产生具有高区域选择性的单磷酸化产物,并且连接基被捕获在树脂上,可以重复使用.
DOI:10.1021/jo048113E

专利信息

专利号:WO-2024185734-A1
优先权日:2023-03-03
标 题:Polyphosphorylated nucleoside, phosphate-activated nucleotide used for synthesis of polyphosphorylated nucleoside and method for synthesis of same, and method for synthesis of polyphosphorylated nucleoside using phosphate-activated nucleotide
发明人：KATAOKA MASANORI; FUKUI CHIHARU; TSUJI YOHEI; FUJIMURA Kazuma
权利人:NATIAS INC
摘要:The present invention provides: a polyphosphorylated nucleoside which has a structure represented by formula (I) and can be efficiently produced by a short process and a simple operation with use of a less expensive material; a phosphate-activated nucleotide which is used for the synthesis of the polyphosphorylated nucleoside and a method for the synthesis of this phosphate-activated nucleotide; and a method for the synthesis of a polyphosphorylated nucleoside using a phosphate-activated nucleotide. In the formula, B represents a protected or unprotected, natural or artificial nucleoside base; R 1 , R 2 , R 4 and R 5 each represent H or an alkyl group or the like, and R 1 , R 2 , R 4 and R 5 may be the same as or different from each other; X and Y each represents H, OH, OCH 3 or the like; h represents an integer of 1 to 3; p, n, m and q each represent 0 or an integer, and p, n, m and q are in no particular order; and (p + n + m + q) is an integer of 0 to 5,000.

专利号:EP-1309698-B1
优先权日:2000-07-21
标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants
发明人：CAHOON EDGAR B
权利人:DU PONT
摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.

专利号:US-8314209-B2
优先权日:2007-12-12
标 题 :Lipid-assisted synthesis of polymer compounds and methods for their use
发明人：RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO
权利人:RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO; UNIV CALIFORNIA
摘要:The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the absence of catalytic enzymes. The method comprises providing an aqueous solution having a plurality of phospholipid molecules and monomer molecules; subjecting the aqueous solution to fluctuating temperature conditions; subjecting the aqueous solution to fluctuating cycles of drying and hydrating conditions; subjecting the aqueous solution to fluctuating [H + ] conditions; the fluctuating conditions thereby allowing formation of a chemical bond between at least two monomers to create a polymer. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

专利号:US-5866378-A
优先权日:1995-10-06
标 题:Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexuloses
发明人：MARQUARDT RUEDIGER; HOERSCH BRIGITTE; SEIFFERT-STOERIKO ANDREAS; STEIN ANDREAS; ZERVOSEN ASTRID; ELLING LOTHAR; KULA MARIA REGINA; VERSECK STEFAN; DISTLER JUERGEN; PIEPERSBERG WOLFGANG
权利人:HOECHST AG
摘要:The present invention relates to processes for the enzymatic synthesis of nucleotide-6-deoxy-D-xylo-4-hexuloses starting from a nucleoside monophosphate (NMP). These processes comprise simultaneous incubation of the following substances in a buffer solution: n (a) substrates comprising a nucleoside monophosphate, phosphoenolpyruvate, adenosine triphosphate, and sucrose; and n (b) enzymes comprising pyruvate kinase, nucleoside-monophosphate kinase, sucrose synthase and deoxythymidine-D-glucose 4,6dehydratase.

专利号:WO-2024165611-A1
优先权日:2023-02-07
标题:Production of a disaccharide and/or milk oligosaccharide by a cell with reduced synthesis of udp-glcnac
发明人：BEAUPREZ JOERI; DECOENE THOMAS; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The invention provides a cell for production of a disaccharide and/or an oligosaccharide like a milk oligosaccharide wherein synthesis of UDP-N-acetylglucosamine in said cell is rendered less functional. The invention further provides use of said cell in a cultivation or incubation. The invention also describes methods for the production of a disaccharide and/or an oligosaccharide like a milk oligosaccharide using said cell as well as the purification of said disaccharide and/or oligosaccharide like a milk oligosaccharide.

专利号:US-4670563-A
优先权日:1984-06-20
标题 :Imidazolides as intermediates for the synthesis of cytotoxic conjugates
发明人：JANSEN FRANZ; GROS PIERRE
权利人:SANOFI SA
摘要:Imidazolides of the formula: ##STR1## in which: E represents an inert spacing structure; and n G represents a group: ##STR2## or a group --S--S--X, in which X is an activating group. Application: synthesis of cytotoxic conjugates.