CAS: 591-80-0; Pent-4-Enoic Acid

相似化合物

821-09-0 1968-40-7 818-57-5

上下游产品

piperidin-2-one 1,3,4-Tribromobutane allylmalonic acid 2-acetyl-pent-4-enoic acid ethyl ester pent-4-enoic acid propyl ester vinyl pent-4-enoate ethyl 4-pentenoate 5-hydroxymethyl-4,5-dihydrofuranone

4-戊烯酸甲酯置于水,Lithium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,反应生成 4-戊烯酸
参考文献:通过exo-Palladacycles反应生成的二齿辅助定向链烯基c-h烯丙基化:支链1,4-二烯的合成†
标题:通过exo-Palladacycles反应生成的二齿辅助定向链烯基c-h烯丙基化:支链1,4-二烯的合成†
摘要:通过使用未活化的(z)烯烃和碳酸烯丙酯,证实了通过exo-Palladacycle中间体进行的烯基ch烯丙基化.通过使用8-氨基喹啉(aq)衍生的酰胺作为指导基团,N,N-双齿螯合辅助的c-h活化方案在温和且无氧化剂的条件下进行,具有优异的选择性.该方法的实用性由制备规模,不可分离的z / E烯烃的选择性转化以及易于除去酰胺助剂以提供相应的酯来证明.
DOI:10.1039/c9Cc07466J

专利信息

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-6835849-B2
优先权日:2002-07-15
标题:Synthesis of alkenoate esters from lactones and alcohols
发明人：MANZER LEO ERNEST
权利人:DU PONT
摘要:The invention relates to the synthesis of alkenoate esters from a corresponding lactone and an alcohol in the presence of a basic catalyst. More specifically, this invention relates to the synthesis of methyl-4-pentenoate ester from 5-methyl butyrolactone and methanol.

专利号:US-9000209-B2
优先权日:2011-07-22
标题:Method of regioselective synthesis of substituted benzoates
发明人：KRAUS GEORGE A
权利人:KRAUS GEORGE A; UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

专利号:US-5811515-A
优先权日:1995-06-12
标 题 :Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis
发明人：GRUBBS ROBERT H; MILLER SCOTT J; BLACKWELL HELEN E
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing conformationally restricted amino acids, peptides, and peptidomimetics by ring closing metathesis. The method includes the steps of synthesizing a peptide precursor containing first and second unsaturated C--C bonds and contacting the peptide precursor with a RCM catalyst to yield a conformationally restricted peptide. Suitable peptide precursors may contain two or more unsaturated C--C bonds. These bonds may be olefinic bonds and may be contained in first and second alkenyl groups which may be allyl groups. The RCM catalyst may be a Ruthenium or Osmium carbene complex catalyst and more specifically, a Ruthenium or Osmium carbene complex catalyst that includes a Ruthenium or Osmium metal center that is in a +2 oxidation state, has an electron count of 16, and is pentacoordinated. The method may be carried out using solid-phase-peptide-synthesis techniques. In this embodiment, the precursor, which is anchored to a solid support, is contacted with a RCM catalyst and the product is then cleaved from the solid support to yield a conformationally restricted peptide.

专利号:WO-9639413-A1
优先权日:1995-05-23
标题 :Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced
发明人：IYER RADHAKRISHNAN P; YU DONG; AGRAWAL SUDHIR; TAN WEITIAN; DEVLIN THERESA; HABUS IVAN
权利人:HYBRIDON INC; IYER RADHAKRISHNAN P; YU DONG; AGRAWAL SUDHIR; TAN WEITIAN; DEVLIN THERESA; HABUS IVAN
摘要:The present invention provides new mononucleotide synthons useful in the synthesis of oligonucleotides having from one to all P-chiral centers that are predominantly and independently in the R or S configuration. The invention also provides methods of synthesizing these synthons, methods of synthesizing oligonucleotides having from one to all P-chiral centers predominantly and independently in the R or S configuration, and such oligonucleotides. Oligonucleotides synthesized with the novel synthons are useful for modulating nucleic acid expression, both in vitro and in vivo, as well as in traditional hybridization assays.