N'-Cbz-L-鸟氨酸置于10Percent Pd/c 氢气,碳酸氢钠体系中,用 甲醇 作为反应溶剂,化学反应生成 (S)-2-乙酰氨基-5-氨基戊酸 参考文献:Is N-Acetylornithine Aminotransferase The Real N-Succinyl-Ll-Diaminopimelate Aminotransferase In Escherichia Coli And Mycobacterium Smegmatis 标题:Is N-Acetylornithine Aminotransferase The Real N-Succinyl-Ll-Diaminopimelate Aminotransferase In Escherichia Coli And Mycobacterium Smegmatis 摘要:我们检查了大肠杆菌和耻垢分枝杆菌中的 N-琥珀酰-Ll-二氨基庚二酸转氨酶 (Dap-At) 和 N-乙酰鸟氨酸转氨酶 (Naco-At) 活性之间的异同,以调查最近关于这两种物质的说法.酶是同一种酶.结果不支持这两种活性由单一酶催化的假设. DOI:10.1039/b106146C
专利号:US-8497098-B2 优先权日:2004-07-15 标题 :Biochemical synthesis of 1,4-butanediamine 发明人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G 权利人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G; DSM IP ASSETS BV 摘要:The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.
专利号:US-2006269975-A1 优先权日:1999-07-16 标 题:Corynebacterium glutamicum genes encoding proteins involved in DNA replication, protein synthesis, and pathogenesis 发明人:POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR 权利人:BASF AG 摘要:Isolated nucleic acid molecules, designated RRP nucleic acid molecules, which encode novel RRP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing RRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated RRP proteins, mutated RRP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of RRP genes in this organism.
专利号:US-2005244935-A1 优先权日:1999-06-25 标题:Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 发明人:POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR 权利人:BASF AG 摘要:Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
专利号:US-2009011478-A1 优先权日:2004-07-15 标 题:Biochemical Synthesis of 1,4-Butanediamine
专利号:WO-2006005603-A1 优先权日:2004-07-15 标 题 :Biochemical synthesis of 1,4-butanediamine
专利号:US-10722441-B2 优先权日:2016-01-15 标题:Noreugenin glycoside derivatives 发明人:CAROLA CHRISTOPHE; SCHULTE MICHAEL; RABAUSCH ULRICH; ROSENFELD HENNING; STREIT WOLFGANG 权利人:UNIV HAMBURG 摘要:A use of noreugenin glycoside derivatives of formulas I, II and III as a self-tanning substance or to increase the synthesis of melanin, improve melanin transport and/or improve the distribution of melanin in suprabasal layers, preparations containing noreugenin glycoside derivatives of formulas I, II and III, and noreugenin glycoside derivatives of formulas I, II and III.
参考文献:10.1186/1471-2164-12-268 摘要:Yin F, Pajak A, Chapman R, Sharpe A, Huang S, Marsolais F. Analysis of common bean expressed sequence tags identifies sulfur metabolic pathways active in seed and sulfur-rich proteins highly expressed in the absence of phaseolin and major lectins. BMC Genomics. 2011 May 26;12():268. 参考文献:10.1186/s12864-015-1957-7 摘要:Shestov M, Ontañón S, Tozeren A. Encyclopedia of bacterial gene circuits whose presence or absence correlate with pathogenicity--a large-scale system analysis of decoded bacterial genomes. BMC Genomics. 2015 Oct 13;16():773. 参考文献:10.1186/s12931-015-0283-6 摘要:Nickler M, Ottiger M, Steuer C, Huber A, Anderson JB, Müller B, Schuetz P. Systematic review regarding metabolic profiling for improved pathophysiological understanding of disease and outcome prediction in respiratory infections. Respiratory Research. 2015 Oct 15;16(1):125. doi: 10.1186/s12931-015-0283-6. 参考文献:10.1007/s10295-018-2037-1 摘要:Shu Q, Xu M, Li J, Yang T, Zhang X, Xu Z, Rao Z. Improved l-ornithine production in Corynebacterium crenatum by introducing an artificial linear transacetylation pathway. Journal of Industrial Microbiology & Biotechnology. 2018 May 04;45(6):393–404. doi: 10.1007/s10295-018-2037-1.