CAS: 6205-08-9; (S)-2-Acetamido-5-Aminopentanoic Acid

该化合物是氨酸或氨基氨酸的衍生物,其特点是在氨基氨基氨基氮原子中添加了乙酰组,它是在水中溶解的白到白的晶状粉,其结构中含有碳,氢,氮和氧原子.此外,该化合物在尿素循环中起着重要作用,它参与合成,并参与各种代谢过程.N-乙酰-L-ornithine经常用于生物化学研究,并有可能在营养和医学领域,特别是在与代谢紊乱和氨酸代谢有关的研究中应用.分子公式反映了其结构,含有碳,氢,氮和氧原子.此外,必须谨慎地处理该化合物,并遵守适当的安全准则,以及任何生物化学物质.总的来说,N-乙基-L-ornithine在生理功能和研究应用中都起着重要的化合物作用.

结构式图片

相似化合物

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CAS号70-26-8 鸟氨酸

合成工艺路线路线简述

    N'-Cbz-L-鸟氨酸置于10Percent Pd/c 氢气,碳酸氢钠体系中,用 甲醇 作为反应溶剂,化学反应生成 (S)-2-乙酰氨基-5-氨基戊酸
    参考文献:Is N-Acetylornithine Aminotransferase The Real N-Succinyl-Ll-Diaminopimelate Aminotransferase In Escherichia Coli And Mycobacterium Smegmatis
    标题:Is N-Acetylornithine Aminotransferase The Real N-Succinyl-Ll-Diaminopimelate Aminotransferase In Escherichia Coli And Mycobacterium Smegmatis
    摘要:我们检查了大肠杆菌和耻垢分枝杆菌中的 N-琥珀酰-Ll-二氨基庚二酸转氨酶 (Dap-At) 和 N-乙酰鸟氨酸转氨酶 (Naco-At) 活性之间的异同,以调查最近关于这两种物质的说法.酶是同一种酶.结果不支持这两种活性由单一酶催化的假设.
    DOI:10.1039/b106146C

    海关参考信息

    专利信息


    专利号:US-8497098-B2
    优先权日:2004-07-15
    标题 :Biochemical synthesis of 1,4-butanediamine
    发明人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G
    权利人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G; DSM IP ASSETS BV
    摘要:The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.

    专利号:US-2006269975-A1
    优先权日:1999-07-16
    标 题:Corynebacterium glutamicum genes encoding proteins involved in DNA replication, protein synthesis, and pathogenesis
    发明人:POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR
    权利人:BASF AG
    摘要:Isolated nucleic acid molecules, designated RRP nucleic acid molecules, which encode novel RRP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing RRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated RRP proteins, mutated RRP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of RRP genes in this organism.

    专利号:US-2005244935-A1
    优先权日:1999-06-25
    标题:Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport
    发明人:POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR
    权利人:BASF AG
    摘要:Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.

    专利号:US-2009011478-A1
    优先权日:2004-07-15
    标 题:Biochemical Synthesis of 1,4-Butanediamine

    专利号:WO-2006005603-A1
    优先权日:2004-07-15
    标 题 :Biochemical synthesis of 1,4-butanediamine

    专利号:US-10722441-B2
    优先权日:2016-01-15
    标题:Noreugenin glycoside derivatives
    发明人:CAROLA CHRISTOPHE; SCHULTE MICHAEL; RABAUSCH ULRICH; ROSENFELD HENNING; STREIT WOLFGANG
    权利人:UNIV HAMBURG
    摘要:A use of noreugenin glycoside derivatives of formulas I, II and III as a self-tanning substance or to increase the synthesis of melanin, improve melanin transport and/or improve the distribution of melanin in suprabasal layers, preparations containing noreugenin glycoside derivatives of formulas I, II and III, and noreugenin glycoside derivatives of formulas I, II and III.
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    合成参考文献


    参考文献:10.1186/1471-2164-12-268
    摘要:Yin F, Pajak A, Chapman R, Sharpe A, Huang S, Marsolais F. Analysis of common bean expressed sequence tags identifies sulfur metabolic pathways active in seed and sulfur-rich proteins highly expressed in the absence of phaseolin and major lectins. BMC Genomics. 2011 May 26;12():268.
    参考文献:10.1186/s12864-015-1957-7
    摘要:Shestov M, Ontañón S, Tozeren A. Encyclopedia of bacterial gene circuits whose presence or absence correlate with pathogenicity--a large-scale system analysis of decoded bacterial genomes. BMC Genomics. 2015 Oct 13;16():773.
    参考文献:10.1186/s12931-015-0283-6
    摘要:Nickler M, Ottiger M, Steuer C, Huber A, Anderson JB, Müller B, Schuetz P. Systematic review regarding metabolic profiling for improved pathophysiological understanding of disease and outcome prediction in respiratory infections. Respiratory Research. 2015 Oct 15;16(1):125. doi: 10.1186/s12931-015-0283-6.
    参考文献:10.1007/s10295-018-2037-1
    摘要:Shu Q, Xu M, Li J, Yang T, Zhang X, Xu Z, Rao Z. Improved l-ornithine production in Corynebacterium crenatum by introducing an artificial linear transacetylation pathway. Journal of Industrial Microbiology & Biotechnology. 2018 May 04;45(6):393–404. doi: 10.1007/s10295-018-2037-1.
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