CAS: 62257-16-3; 3-Amino-4-Fluorophenol

该化合物是一种有机化合物,其特征是存在一个氨基氨基化合物(-NH2)和一个附属于苯球环的氟原子,该化合物一般是一种固体,可溶解于极地溶剂中,因为氢氧化物和氨基酚组可以进行氢联结;氟原子具有独特的电子特性,影响化合物的再活动性和潜在应用;3-氨-4-氟苯酚经常用于染料,药物和农用化学合成,因为它能够参与各种化学反应,例如核聚变和合合反应;此外,氨基和氢氧功能组的存在允许进一步衍生,使其在有机合成中成为多用途中间体;应参考安全数据,如任何化学品,以了解其处理和潜在危害.

英文名称3-Amino-4-Fluorophenol
中文名称3-氨基-4-氟苯酚
IUPAC名称3-amino-4-fluorophenol
其它别名3-氨-4-氟苯酚; 6004 3-Amino-4-Fluoro Phenol
CAS编号62257-16-3
MFCD编号:MFCD09033850
EINECS号:690-814-8
分子式:C6H6FNO
分子量:127.12
产品CID: 1604702
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: VJCSFNNTQGRAKH-UHFFFAOYSA-N
InChI=1S/C6H6FNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2…
计算化学: 氢键受体数2.0氢键供体数2可旋转键数0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别3(吸入)
急性毒性类别3(经皮)
急性毒性类别3(经口)
急性毒性类别4(经口)
急性毒性类别4(吸入)
急性毒性类别4(经皮)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
H302 |吞咽有害.
H332 |吸入有害.
H312 |皮肤接触有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xn
风险等级Toxic
危险类别码22

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 3-Amino-4-Fluorophenol 主要起始原料 4-Fluoro-3-Nitrophenol
84478-88-6 = 62257-16-3 + 84478-72-8
反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; Rt -> 5 °C; < 15 °C; 1 H,0 - 10 °C1.2 Solvents: Water; < 25 °C; 1 H,0 - 10 °C2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 10 Min,20 - 40 °C; 1.5 H,30 - 40 °C3.1 Reagents: Hydrogen,Hydrochloric Acid Catalysts: Palladium Solvents: Methanol; 4 H,0.1 Mpa,15 - 25 °C
标题:Development Of A Scalable Synthesis Of A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor: Efficient Construction Of A 6-Etherified [1,2,4]Triazolo[1,5-A]Pyridine-2-Amine Core
作者:Ishimoto,Kazuhisa; Et Al
参考文献:Organic Process Research & Development 日期:2014 卷标:18(1) 页码:122-134]

84478-75-1 = 62257-16-3 + 84478-72-8
反应条件:1.1 Reagents: Hydrogen,Hydrochloric Acid Catalysts: Palladium Solvents: Methanol; 4 H,0.1 Mpa,15 - 25 °C
标题:Development Of A Scalable Synthesis Of A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor: Efficient Construction Of A 6-Etherified [1,2,4]Triazolo[1,5-A]Pyridine-2-Amine Core
作者:Ishimoto,Kazuhisa; Et Al
参考文献:Organic Process Research & Development 日期:2014 卷标:18(1) 页码:122-134]

84478-89-7 = 62257-16-3 + 84478-72-8
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 10 Min,20 - 40 °C; 1.5 H,30 - 40 °C2.1 Reagents: Hydrogen,Hydrochloric Acid Catalysts: Palladium Solvents: Methanol; 4 H,0.1 Mpa,15 - 25 °C
标题:Development Of A Scalable Synthesis Of A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor: Efficient Construction Of A 6-Etherified [1,2,4]Triazolo[1,5-A]Pyridine-2-Amine Core
作者:Ishimoto,Kazuhisa; Et Al
参考文献:Organic Process Research & Development 日期:2014 卷标:18(1) 页码:122-134]

1996-41-4 = 62257-16-3 + 84478-72-8
反应条件:1.1 Reagents: Sodium Carbonate Solvents: Water; Rt -> 45 °C; 1 H,45 °C; 45 °C -> 10 °C1.2 10 - 25 °C2.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; Rt -> 5 °C; < 15 °C; 1 H,0 - 10 °C2.2 Solvents: Water; < 25 °C; 1 H,0 - 10 °C3.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 10 Min,20 - 40 °C; 1.5 H,30 - 40 °C4.1 Reagents: Hydrogen,Hydrochloric Acid Catalysts: Palladium Solvents: Methanol; 4 H,0.1 Mpa,15 - 25 °C
标题:Development Of A Scalable Synthesis Of A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor: Efficient Construction Of A 6-Etherified [1,2,4]Triazolo[1,5-A]Pyridine-2-Amine Core
作者:Ishimoto,Kazuhisa; Et Al
参考文献:Organic Process Research & Development 日期:2014 卷标:18(1) 页码:122-134

2-氯-4-氟苯酚置于5-硝基-2-甲基苯酚,硫酸,Palladium 10% On Activated Carbon,水,氢气,Sodium Hydroxide体系中,用乙醇,水作为反应溶剂,-10.0 °C,344.75 Kpa 条件下,反应 16.5H,反应生成 3-氨基-4-氟苯酚
参考文献: Methods And Compositions For The Treatment Of Myeloproliferative Diseases And Other Proliferative Diseases[fr] Méthodes Et Compositions Pouvant être Utilisées En Vue Du Traitement De Maladies Myéloprolifératives Et D'Autres Maladies Prolifératives
标题: Methods And Compositions For The Treatment Of Myeloproliferative Diseases And Other Proliferative Diseases[fr] Méthodes Et Compositions Pouvant être Utilisées En Vue Du Traitement De Maladies Myéloprolifératives Et D'Autres Maladies Prolifératives

海关参考信息

2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
2905199090-其他饱和一元醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

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优先权日:1984-01-21
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