专利号:WO-9000622-A1 优先权日:1988-07-08 标题 :Oligonucleotide hybridization probes and means for the synthesis of the most preferred probes 发明人:KWIATKOWSKI MAREK; SUND CHRISTIAN; HURSKAINEN PERTTI 权利人:WALLAC OY; PHARMACIA AB 摘要:Oligonucleotide probe labeled at one of its teminal positions with a non-linear branched polymer carrying a plurality of negatively charged groups, preferably phosphodiester groups, and optionally also analytically indicatable groups covalently linked to terminal ends of the branches of said polymer. The preferred indicatable groups are lanthanide chelates. A compound that can be used for the synthesis of the probe is also disclosed. The compound has formula (I), where R1 and R2 are lower alkyl; R3 is lower alkyl (C1-C7), or aryl each of which optionally being provided with electron-withdrawing substituents; and A1, A2 and A3 are hydrogen, A'-O-B, A''-O-B or A'''-O-B, at most one of A1-3 being hydrogen and A', A'' and A''' being a hydrocarbon chain providing a distance of 5-9 atoms between the phosphorous atom and the oxygen directly bound to B, and B being a protecting group. In the preferred compound at least two of A1-3 are identical while the other is hydrogen.
专利号:US-5539117-A 优先权日:1993-04-13 标题:2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines 发明人:SNOW ROBERT A; DELECKI DANIEL J; SHAH CHANDRA R; HOLLISTER K ROBERT 摘要:The present invention is directed to 2-acetyl-6-cyanopyridine compounds that are useful as intermediates in the synthesis of oligo-2,6-pyridines. The present invention is also directed to new, simpler, less expensive methods for synthesizing such oligopyridines using the novel 2-acetyl-6-cyanopyridine compounds as intermediates.
专利号:US-4981985-A 优先权日:1987-10-20 标题 :Synthesis of photolabile chelators for multivalent cations 发明人:KAPLAN JACK H; ELLIS-DAVIS GRAHAM C R 权利人:UNIV PENNSYLVANIA 摘要:A method of synthesizing photolabile chelators as EDTA and EGTA derivatives to be used in caging multivalent cations is disclosed. The chelators chelate the cations forming non-biologically active compounds. The chelated compounds can then be localized in or near biological systems. Upon irradiation, the chelated compound cleaves with the subsequent cleaved remainders having a substantially lower affinity for the chelated cation. Large amounts of cation are thus rapidly released and the effect of such concentration jumps on the biological system can be accurately studied.
专利号:CN-104854117-B 优先权日:2012-07-17 标题 :Process for the synthesis of N-phosphonomethyliminodiacetic acid
专利号:RU-2591197-C1 优先权日:2015-04-01 标题:Method for synthesis of heterothreenuclear coordination compound based on iminodiacetic acid salicylidenhydrazone
专利号:EP-0378652-A1 优先权日:1988-07-08 标 题 :Oligonucleotide hybridization probes and means for the synthesis of the most preferred probes