CAS: 942195-86-0; 4-Hydroxy-N,N,2-Trimethyl-1-Tosyl-1H-Benzo[d]Imidazole-6-Carboxamide

• 英文名称4-Hydroxy-N,N,2-Trimethyl-1-Tosyl-1H-Benzo[d]Imidazole-6-Carboxamide
• 中文名称替戈拉生杂质19
• IUPAC名称4-hydroxy-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide
• 其它别名7-Hydroxy-N,N,2-Trimethyl-3-Tosyl-3H-Benzo[d]Imidazole-5-Carboxamide; 4-Hydroxy-N,N,2-Trimethyl-1-Tosyl-1H-Benzo[d]Imidazole-6-Carboxamide; 4-Hydroxy-N N,2-Trimethyl-1-[(4-Methylphenyl)Sulfonyl]-1H-Benzimidazole-6-Carboxamide; 1H-Benzimidazole-6-Carboxamide, 4-Hydroxy-N,N,2-Trimethyl-1-[(4-Methylphenyl)Sulfonyl]-; Tegoprazan Impurity 19; 4-Hydroxy-N,N,2-Trimethyl-1-Tosylbenzimidazole-6-Carboxamide; 4-Hydroxy-N,N, 2-Trimethyl-1-P-Toluenesulfonyl-1H-Benzo [d] Imidazole-6-Formamide; N-Ts Tegoprazan Parent Nucleus
• CAS编号942195-86-0
• MFCD编号:MFCD20260231
• FDA UNII编号:9AU45YBJ8M
• 分子式:C18H19N3O4S
• 分子量:373.43
• 产品CID: 1990640
• 产品分类有机原料 → 苯类化合物 → 苯和取代衍生物

• 相似结构搜索
• InChIKey: AGWVNJPTTKMUQO-UHFFFAOYSA-N
• InChI=1S/C18H19N3O4S/c1-11-5-7-14(8-6-11)26(24,25)21-12(2)19-17-15(21)9-13(10-16(17)22)18(23)20(3)4/h5-10,22H,1-4H3…
• 计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数3.0

物理性质

• 沸点654.0±65.0 °C(预测)
• 密度1.36±0.1 g/cm3(预测)
• pKa:7.07±0.40(预测)
• LogP:2.5
• 外观形态白色至类白色固体
• 储存条件2-8°C, 密封存储, 防潮
• 产品应用该化合物用于治疗受酸泵影响,具有对抗性活动的条件,如胃肠道紊乱,胃-眼科障碍,胃----阴道复流病,喉病,呼吸道呼吸道复发病,胃溃疡,胃肺癌,二元肺病等.

MSDS等安全信息

• GHS符号GHS08,GHS02
• 警示词Danger
• 危险描述H304-H226
• 防范说明P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P331-P303+P361+P353-P301+P310-P403+P235-P405

合成工艺路线路线简述

• 合成目标产物 7-Hydroxy-N,N,2-Trimethyl-3-Tosyl-3H-Benzo[d]Imidazole-5-Carboxamide 主要起始原料 4-(Benzyloxy)-N,N,2-Trimethyl-1-Tosyl-1H-Benzo[d]Imidazole-6-Carboxamide
• 942195-85-9 = 942195-86-0
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Tetrahydrofuran; 30 H,1 Atm,Rt
  标题:Spiro Benzimidazole Derivatives As Acid Pump Inhibitors And Their Preparation
  参考文献:World Intellectual Property Organization]
  
  942195-85-9 = 942195-86-0
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Tetrahydrofuran; 30 H,Rt
  标题:Preparation Of Benzimidazole Derivatives As Selective Acid Pump Inhibitors
  参考文献:World Intellectual Property Organization]
  
  942195-85-9 = 942195-86-0
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Tetrahydrofuran; 30 H,1 Atm,Rt
  标题:Chromane Substituted Benzimidazole Derivatives With Acid Pump Antagonistic Activity
  参考文献:United States]
  
  942195-85-9 = 942195-86-0
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Tetrahydrofuran; 24 H,1 Atm,Rt; 6 H,1 Atm,Rt
  标题:Preparation Of Tegprazan Intermediate
  参考文献:China]
  
  2766111-08-2 = 942195-86-0
  反应条件:1.1 Reagents: Ammonia Solvents: Methanol,Water; 20 - 30 °C; 30 °C -> 5 °C; 16 H,Ph 10 - 10.2,3 - 5 °C
  标题:Benzimidazole Derivatives And Their Preparation
  参考文献:World Intellectual Property Organization]
  
  = 942195-86-0 [标题:Reaction Conditions
  标题:Benzimidazole Derivatives As Selective Acid Pump Inhibitors
  参考文献:United States

海关参考信息

• 2912110000-甲醛
  2912210000-苯甲醛
  2924191000-二甲基甲酰胺
  2908199090-其他酚的卤化衍生物
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管