CAS: 1001264-89-6; (S)-2-(4-Chlorophenyl)-1-(4-((5R,7R)-7-Hydroxy-5-Methyl-6,7-Dihydro-5H-Cyclopenta[d]Pyrimidin-4-yl)Piperazin-1-yl)-3-(Isopropylamino)Propan-1-One

上下游产品

Tert-Butyl ((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-Hydroxy-5-Methyl-6,7-Dihydro-5H-Cyclopenta[d]Pyrimidin-4-yl)Piperazin-1-yl)-3-Oxopropyl)(Isopropyl)Carbamate 1001270-64-9
Tert-Butyl 4-((5R,7R)-7-Hydroxy-5-Methyl-6,7-Dihydro-5H-Cyclopenta[d]Pyrimidin-4-yl)Piperazine-1-Carboxylate 1001180-45-5
Tert-Butyl 4-((5R)-7-Hydroxy-5-Methyl-6,7-Dihydro-5H-Cyclopenta[d]Pyrimidin-4-yl)-Piperazine-1-Carboxylate 1001180-18-2
Tert-Butyl 4-((5R,7R)-5-Methyl-7-((4-Nitrobenzoyl)Oxy)-6,7-Dihydro-5H-Cyclopenta[d]Pyrimidin-4-yl)-Piperazine-1-Carboxylate 1001180-47-7
(R)-4-(5-甲基-7-氧代-6,7-二氢-5H-环戊烷并[d]嘧啶-4-基)哌嗪-1-羧酸叔丁酯 (R)-Tert-Butyl 4-(5-Methyl-7-Oxo-6,7-Dihydro-5H-Cyclopenta[d]Pyrimidin-4-yl)Piperazine-1-Carboxylate 1001180-21-7
(R)-Tert-Butyl 4-(6-Chloro-5-(4-Methoxy-4-Oxobutan-2-yl)Pyrimidin-4-yl)Piperazine-1-Carboxylate

Methyl 2-(4-Chlorophenyl)Acrylate置于盐酸,Lithium Hydroxide,正丁基锂,水,双氧水,N,N-二异丙基乙胺体系中,用 四氢呋喃,1,4-二氧六环,Hexanes,二氯甲烷 用作溶剂,化学反应 5.17H,反应生成帕他色替
参考文献:Wo2008/6040
标题:Wo2008/6040

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-2024174678-A1
优先权日:2020-06-30
标 题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

专利号:AR-124856-A2
优先权日:2014-09-26
标题 :PROCESS FOR PREPARING AN INTERMEDIATE COMPOUND FOR THE SYNTHESIS OF (CYCLOPENTYL[D]PYRIMIDIN-4-IL)PIPERAZINE COMPOUNDS

专利号:US-2022047711-A1
优先权日:2018-12-10
标题 :Photocrosslinking peptides for site specific conjugation to fc-containing proteins
发明人：SADOWSKY JACK; ZACHARIAS NEELIE TYANA
权利人:GENENTECH INC
摘要:Provided herein are peptides having a photocrosslinking moiety useful for the synthesis of antibody-drug conjugates as well as methods of making and using such conjugates.