专利号:WO-9939201-A1 优先权日:1998-02-03 标 题 :SOLUTION AND SOLID PHASE SULFOXIDE GLYCOSYLATION: SYNTHESIS OF β-LINKED OLIGOSACCHARIDES USING 2-DEOXY-2-N-TRIFLUOROACETAMIDO-GLYCOPYRANOSYL DONORS 发明人:SILVA DOMINGOS; SOFIA MICHAEL J 权利人:INTERCARDIA RESEARCH LAB INC 摘要:The invention relates to a process for the synthesis of β-oligosaccharides. β-oligosaccharides are synthesized using alkylsulfenyl- or an arylsulfenyl-2-deoxy-2-N-trifluoroacetamidoglycopyranoses as glycosyl donors via the sulfoxide glycosylation, both in solution and solid phases. Once activated under the glycosylation conditions, these donors afford the respective β-glycosides exclusively and in high yield. Since the trifluoroacetamido group is easily removed under mild conditions, the corresponding amino group can be appropriately derivatized, even in the presence of unprotected hydroxyl groups. Disaccharide libraries are designed, constructed and analyzed. The invention also relates to a process for synthesizing the glycosyl donor.
专利号:US-9359370-B2 优先权日:2008-07-08 标题 :Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof 发明人:WANG YINXIANG; XIE GUOJIAN; DING LIEMING; TAN FENLAI; HU YUNYAN; HE WEI; HAN BIN; LONG WEI; LIU YONG; Ai haima; DAVIS CHARLES; ZHANG DON 权利人:BETA PHARMA INC 摘要:The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
专利号:US-2009220792-A1 优先权日:2006-01-20 标题 :Synthesis of Alloyed Nanocrystals in Aqueous or Water-Soluble Solvents 发明人:YING JACKIE Y; ZHENG YUANGANG 权利人:SINGAPORE AGENCY FOR SCIENCE T 摘要:The present invention relates to nanocrystals and methods for making the same; in particular, the invention relates to ternary or higher alloyed nanocrystals and methods for making such structures in aqueous or water-soluble solvents. In certain embodiments of the invention, methods of preparing ternary or higher alloyed nanocrystals involve providing at least first, second, and third nanocrystal precursors (e.g., NaHSe, ZnCl 2 , and CdCl 2 ) and forming nanocrystal structures in an aqueous or water-soluble solvent. In some cases, nanocrystal precursor solutions may also include a water-soluble ligand (e.g., glutathione, GSH). As such, ternary or higher alloyed nanocrystals (e.g., Zn x Cd)— x Se) comprising the at least first, second, and third nanocrystal precursors may be formed, and the water-soluble ligand may coat at least a portion of the surface of the ternary or higher alloyed nanocrystal. Advantageously, methods for forming nanocrystals described herein can be performed at low temperatures (e.g., less than 100 degrees Celsius), and, in some embodiments, do not require the use of organic solvents. The present inventors have applied these methods to prepare blue-emitting nanocrystals with emissions that are tunable between 400-500 nm, and with quantum yields of greater than 25% in aqueous solution. These nanocrystals may be highly water soluble and can be used in a variety of applications, including those involving cell culture, sensing applications, fluorescence resonance energy transfer, and in light-emitting devices.
专利号:US-3641142-A 优先权日:1968-10-30 标题 :Pyrogenic synthesis of perfluoroacrylyl fluoride 发明人:ENGLAND DAVID C 权利人:DU PONT 摘要:PROCESS FOR PREPARING PERFLUOROACRYLYL FLUORIDE BY THE PYROLYSIS, E.G., AT 350*-800* C., OF A-HYDROTETRAFLUOROPROPIONIC ACID ANHYDRIDE OR A-HYDROTETRAFLUOROPROPIONYL FLUORIDE PREFERABLY WITH A TWO-COMPONENT CATALYST SYSTEM, E.G., QUARTZ AND AN ALKALI METAL FLUORIDE.
专利号:US-2023028670-A1 优先权日:2021-07-16 标 题 :Method of manufacturing multi-component semiconductor nanocrystal, multi-component semiconductor nanocrystal, and quantum dot including the same 发明人:LEE BAEKHEE; LYU JAEJIN; LEE JUNWOO; LEE TAEKJOON 权利人:SAMSUNG DISPLAY CO LTD 摘要:Provided are a method of manufacturing a multi-component semiconductor nanocrystal, a multi-component semiconductor nanocrystal manufactured by the method, and a quantum dot including the same. The method includes irradiating microwaves to a semiconductor nanocrystal synthesis composition, and the semiconductor nanocrystal synthesis composition includes a precursor including a Group I element, a precursor including a Group II element, a precursor including a Group III element, a precursor including a Group V element, a precursor including a Group VI element, or any combination thereof.
专利号:US-2018208543-A1 优先权日:2017-01-26 标 题 :New method for synthesis of fenfluramine, and new compositions comprising it 发明人:PALOMBI GIOVANNI; ZAGAMI MICHAEL 权利人:FRAU PHARMA S R L 摘要:A new process for preparing the fenfluramine molecule and new compositions containing fenfluramine obtainable with the claimed process.
摘要:Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases., 25(7)(27), 1981 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present 摘要:Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London: Williams and Wilkins, 1982., p. 12 摘要:U.S. Department of Transportation. 2012 Emergency Response Guidebook. Washington, D.C. 2012 摘要:Fire Protection Guide to Hazardous Materials. 12 ed. Quincy, MA: National Fire Protection Association, 1997., p. 491-44