CAS: 1200-22-2; (R)-5-(1,2-Dithiolan-3-yl)Pentanoic Acid

相似化合物

1077-27-6 1077-28-7 2319-84-8

上下游产品

CAS号99427-00-6 1,2-Dithiolane-... | CAS号104726-74-1 ethyl (R)-(+)-α... | CAS号1225192-30-2 (R)-5-[1,2]dith... | CAS号1225192-32-4 (R)-5-[1,2]dith... | CAS号1225192-34-6 (R)-5-[1,2]dith... | CAS号1225192-38-0 (R)-5-[1,2]dith... | CAS号1225192-41-5 (R)-5-[1,2]dith... | CAS号1225192-43-7 (R)-5-[1,2]dith... | CAS号1225192-45-9 (R)-5-[1,2]dith... | CAS号129706-46-3 lipoyl-4-aminob... | CAS号119365-69-4 (R)-6,8-二巯基辛酸

(R)-5-[1,2]Dithiolan-3-Yl-Pentanoic Acid Propylamide置于protein Extract Of Mouse Liver Homogenate 水体系中,用 二甲基亚砜 用作溶剂,化学反应 24.0H,反应生成R-(+)-硫辛酸
参考文献: Alpha-Lipoic Acid Derivatives And Their Use In Drug Preparation[fr] Dérivés De L'Acide Alpha-Lipoïque Et Leur Utilisation Dans La Préparation De Médicaments
标题: Alpha-Lipoic Acid Derivatives And Their Use In Drug Preparation[fr] Dérivés De L'Acide Alpha-Lipoïque Et Leur Utilisation Dans La Préparation De Médicaments
摘要:本发明涉及化合物formula (I)的对映异构体r,其中x为-Nh-R1或formula (V)或(Vi),R1为-(Ch2)N-R2,R2为线性,支链或环状的c1-C6脂肪族基团,-O-(Ch2)N-Ch3,-Nh-Co-(Ch2)N-Ch3,一个含有杂原子的5-或6-成员脂肪族或芳香环,或者一个被一个或两个取代基取代的5-或6-成员芳香环,所述取代基选自-Oh,-O(烷基c1-C3)和-oco(烷基c1-C3),或formula (V),R3为h或c1-C3脂肪族基团,R4为线性c1-C3或支链c3-C12脂肪族基团,或者r3为c1-C3脂肪族基团,R4为线性c1-C12脂肪族基团,Y为o,Ch-(Ch2)N-Ch3或n(Co)(Ch2)N-Ch3,N为0到6的整数.已经发现,本发明的对映异构体能够释放(R)-α-硫辛酸,确保药理活性原则在体内比直接给药获得的更长持续时间,或者模拟硫辛酸本身的药理作用,同时表现出更强烈和持久的活性.

专利信息

专利号:US-12188072-B2
优先权日:2018-03-19
标题 :Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
发明人：JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN
权利人:UNIV NORTHWESTERN; UNIV CORNELL
摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

专利号:US-12365930-B2
优先权日:2016-07-14
标题:Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates
发明人：JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN
权利人:UNIV NORTHWESTERN; UNIV CORNELL
摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

专利号:US-2023373003-A1
优先权日:2022-05-17
标 题 :Seedless Synthesis of Anisotropic Gold Nanoflowers with Cellular Control and Drug Delivery Applications
发明人：OH EUNKEU; SUSUMU KIMIHIRO; SANGTANI AJMEETA; ROGERS Katherine; NAG OKHIL K; LEE KWAHUN; VURGAFTMAN IGOR; WEIBLEN R JOSEPH; KIM MIJIN; DELEHANTY JAMES B
权利人:US GOV SEC NAVY
摘要:A new seedless synthesis of anisotropic nanoscale gold nanoflower (AuNF) particles uses bidentate thiolate ligands to protect the nanoparticle surface and a combination of reagents (for example, ligand, ascorbic acid, and hydroxide) to synthesis AuNF with controlled size and anisotropic properties. Compared to prior art gold nanospheres, AuNF produced approximately a 15-fold improvement in a drug delivery assay.

专利号:WO-2023102600-A1
优先权日:2021-12-06
标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
发明人：ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
权利人:NEWSOUTH INNOVATIONS PTY LTD
摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:US-2016075680-A1
优先权日:2013-04-30
标题:Modified solid support for the synthesis of oligonucleotides
发明人：SOMOZA CALATRAVA ALVARO; LATORRE LOZANO ALFONSO
权利人:FUNDACIÓN IMDEA NANOCIENCIA; FUNDACION IMDEA NANOCIENCIA
摘要:The present invention refers to a new solid support for the synthesis of oligonucleotides, to a method for its preparation and to its use in the solid phase synthesis of oligonucleotides.