CAS: 133775-25-4; (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-yl)Butane-2,3-Diol

相似化合物

135270-11-0 135270-05-2 161346-23-2

上下游产品

(2R,3R)-3-(Benzyloxy)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-yl)-2-Butanol
(R)-2-(2,4-二氟苯基)-3-[1H-1,2,4]三唑-1-基丙烷-1,2-二醇 (R)-2-(2,4-Difluorophenyl)-3-(1H-1,2,4-Triazol-1-yl)Propane-1,2-Diol 141113-41-9
(2R,3R)-3-(Tert-Butyldimethylsilyloxy)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-yl)-2-Butanol 583858-31-5
1-(((2S,3R)-2-(2,4-二氟苯基)-3-甲基环氧乙基-2-基)甲基l)-1H-1,2,4-三唑 (2S,3R)-2-(2,4-Difluorophenyl)-3-Methyl-2-<(1H-1,2,4-Triazol-1-yl)Methyl>Oxirane 135270-07-4
(3R)-2-(2,4-Difluorophenyl)-3-(3,4,5,6-Tetrahydro-2H-Pyran-2-Yloxy)-1-(1H-1,2,4-Triazol-1-yl)2-Butanol 844879-56-7
(2R,3R)-2-(2,4-二氟苯基)-3-((四氢-2H-吡喃-2-基)氧基)-1-(1H-1,2,4-三唑-1-基)丁烷-2-醇 (3R)-2-(2,4-Difluorophenyl)-3-(Tetrahydropyran-2-Yloxy)-1-[1,2,4]Triazol-1-Yl-Butan-2-Ol 135133-23-2
(R)-2-(2,4-Difluorophenyl)-2-Hydroxy-3-(1H-1,2,4-Triazol-1-yl)Propanal
艾菲康唑杂质2 (1R)-1-<(2R)-2-(2,4-Difluorophenyl)-2-Oxiranyl>Ethanol 126918-35-2 (1S)-1-<(2R)-2-(2,4-Difluorophenyl)-2-Oxiranyl>Ethanol 126918-33-0

在 Lithium Hydroxide体系中,用 N,N-二甲基乙酰胺 用作溶剂,化学反应 6.5H,反应生成(2R,3R)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)丁烷-2,3-二醇
参考文献:トリアゾール化合物の製造方法
标题:トリアゾール化合物の製造方法
摘要:提供一种新的制备方法,用作药物中间体的有用三唑化合物.通过将乳酸衍生物与氯化亚砜反应,在氯化铝存在下使1,3-二氟苯反应得到酮衍生物,经过韦特希试剂的烯烃化反应转化为化合物(2),然后经过环氧化和三唑化反应转化为化合物(1)的制备方法.[选定图]无

专利信息

专利号:US-6133485-A
优先权日:1998-04-15
标 题:Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
发明人：SINGH INDER PAL; SIDHU INDERJIT; PALAK BHUPINDER; MICETICH RONALD G
权利人:SYNPHAR LAB INC; TAIHO PHARMACEUTICALS CO LTD
摘要:The asymmetric production of pure diastereomeric (2R,3R), (2R,3S), (2S,3R) and (2S,3S)-2-aryl-1-substituted butan-2,3-diols from the derivatives of lactic acid.

专利号:WO-9952840-A1
优先权日:1998-04-15
标题 :Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols

专利号:EP-1071640-B1
优先权日:1998-04-15
标题 :Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols

专利号:EP-1071640-A1
优先权日:1998-04-15
标题:Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols

专利号:RU-2039050-C1
优先权日:1989-09-26
标 题:Derivatives of 1,2,4-triazole, optically inert or containing r- or s-configuration at c-2 and c-3 asymmetric centers, or their salts showing fungicide activity, and a method of their synthesis

专利号:CN-119528849-A
优先权日:2024-11-28
标题:Intermediate of difluprednate asymmetric synthesis method of body