CAS: 1435-46-7; 3,5-Dichlorofluorobenzene

相似化合物

1435-43-4 3107-21-9 2367-80-8

上下游产品

CAS号626-43-7 3,5-二氯苯胺 | CAS号591-35-5 3,5-二氯苯酚 | CAS号108-70-3 均三氯苯 | CAS号1345732-63-9 3-(3-chloro-5-f...

3,5-二氯苯胺置于盐酸,Fluoroboric Acid,Sodium Nitrite体系中,用 水,邻二氯苯 用作溶剂,化学反应 0.03H,以87%的收率获得3,5-二氯氟苯
参考文献:用于balz-Schiemann反应的连续流反应器:制备芳族氟化物的新程序
标题:用于balz-Schiemann反应的连续流反应器:制备芳族氟化物的新程序
摘要:建立了通过两个连续流动反应器通过balz-Schiemann反应制备芳族氟化物的简便高效方法.连续重氮化反应器在约25oc下运行,停留时间为10-20 S,连续氟脱氮反应器以1分钟的停留时间进行高收率.通过提高温度可以大大缩短反应时间,从而充分利用连续流系统的卓越质量和传热能力.
Doi:10.1016/j.Tetlet.2012.12.084

专利信息

专利号:US-7393980-B2
优先权日:2001-05-17
标题:Use of a composition of an ionic nature as a substrate reagent, a composition constituting a fluorination reagent and a method using same
发明人：GARAYT MAXIME; LE BOULAIRE VIRGINIE; GREE DANIELLE; GREE RENE; SCHANEN VINCENT; SPINDLER JEAN-FRANCIS
权利人:RHODIA CHIMIE SA
摘要:The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comprising at least four carbon atoms. The invention can be used for the synthesis of fluoride derivatives.

专利号:US-7217842-B2
优先权日:2001-04-12
标题:Catalysts for nucleophilic substitution, synthesis thereof, composition containing them and use thereof
发明人：SCHANEN VINCENT; CRISTAU HENRI-JEAN; TAILLEFER MARC
权利人:RHONE POULENC CHIMIE
摘要:The invention concerns novel catalysts for aromatic nucleophilic substitution. Said catalysts are compounds of the general formula (I), wherein: R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , identical or different, are selected among hydrocarbon radicals; the Pn's, advantageously the same, are selected among metalloid elements of column V of a period higher than nitrogen; Z is a metalloid element of column V, advantageously distinct from Pn; preferably a nitrogen (N, P, As, Sb). The invention is applicable to organic synthesis

专利号:US-5968736-A
优先权日:1992-10-01
标 题 :Methods for recording the reaction history of a solid support
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:COLD SPRING HARBOR LAB; UNIV COLUMBIA
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-6165778-A
优先权日:1993-11-02
标 题 :Reaction vessel agitation apparatus
发明人：KEDAR HAIM
权利人:AFFYMAX TECH NV
摘要:A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and transferred to a plurality of reaction vessels 201-209 in one or more reaction vessel banks where monomer addition reactions take place. Optionally, the substrates may be tagged with a tag monomer. A vortexing motor 300 vortexes the contents of reaction vessels 201-209 during monomer addition reactions to enhance synthesis. After the desired monomer and/or tag monomer addition reaction, the suspension is pressurized with argon and transferred back to parent vessel 200 for mixing. Thereafter, the suspension may be pressurized with argon and reallocated among reaction vessels 201-209 for further synthesis.

专利号:US-6503759-B1
优先权日:1992-10-01
标题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C; WIGLER MICHAEL H
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-5721099-A
优先权日:1992-10-01
标 题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.