专利号:US-2021107859-A1 优先权日:2018-04-06 标题 :A process for the synthesis of carbon labeled organic compounds 发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.
专利号:WO-2020246902-A1 优先权日:2019-06-07 标 题 :An initiator of atrp radical polymerisation, a method of its synthesis, and a method of synthesis of low-dispersion polymer and copolymer using this initiator 发明人:MEGIEL ELÅ»BIETA; ROMAŃSKI JAN; FEDORCZUK MAGDALENA 权利人:UNIV WARSZAWSKI 摘要:An initiator of ATRP radical polymerisation having a functional group with a substituent active in polymerisation process, is characterised in that it is a bifunctional initiator containing at least two functional groups separated by a hydrocarbon moiety Y, where the first functional group has an active substituent X and the second functional group has a protecting group Z, which can be chemically modified with the same or a different substituent than the active substituent X present in the first functional group. A method of synthesis of 2-chloro-N-(2-hydroxyethyl)propionamide initiator, NCPAE, is characterised in that ethanolamine is subjected to an acylation reaction with 2-chloropropionyl chloride in presence of triethylamine (TEA), wherein the reaction is carried out under inert atmosphere at room temperature.
专利号:US-7452994-B2 优先权日:2001-09-12 标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings 发明人:MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN 权利人:ANORMED INC 摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
专利号:US-11725070-B2 优先权日:2018-05-09 标 题:Polymerization process for the synthesis of vinyl aromatic polymers with a controlled structure 发明人:GHELFI FRANCO; FERRANDO ANGELO; LONGO ALDO; BUFFAGNI MIRKO 权利人:VERSALIS SPA 摘要:The present invention relates to a polymerization process for the synthesis of vinyl aromatic polymers, in which the sequence of monomers in the chain and the linear, branched soluble, or crosslinked insoluble structure, with reactive or different polarity functions, are controlled. Said process comprises the step of polymerizing vinyl aromatic monomers by means of an Atom Transfer Radical Polymerization (ATRP) reaction with an Activator ReGenerated by Electron Transfer (ARGET), the reaction being carried out at a temperature comprised between 25° C. and 110° C. in an inert gas atmosphere in the presence of a complex catalyst containing a cupric halide and a multidentate amine ligand, feeding to the reaction an organic initiator having two geminal halogens, an alkali metal (bi)carbonate, a solvent pair of an aliphatic alcohol and an acetic ester of the same aliphatic alcohol and possibly ascorbic acid, provided that no initiator is used with three or more active halogens, or polyvinyl monomers or inimers.
专利号:US-2024024493-A1 优先权日:2022-06-22 标 题 :Purification methods for large scale synthesis of cucurbit[7]uril-peg conjugates 发明人:WEBBER MATTHEW J 权利人:PORTAL INSULIN LLC 摘要:Methods of purification for the large scale synthesis of CB[ 7 ]-PEG may include at least one of diafiltration or tangential flow filtration, column chromatography, affinity “pull-downâ€? techniques, or selective precipitation methods. In one embodiment, the method includes providing a reaction mixture containing synthesized CB[ 7 ]-PEG, providing a membrane selected to be below the nominal molecular weight of CB[ 7 ]-PEG, and removing small molecular weight contaminant species from the reaction mixture using the membrane. In embodiments, regardless of which purification method is used, a copper catalyst component of the “clickâ€? chemistry reaction mixture may be removed using a commercially available metal-chelating resin.
专利号:US-6610802-B2 优先权日:2001-05-29 标题 :Process for synthesis of polymer compositions, polymer compositionS obtainable by the process, and use of the same 发明人:ROOS SEBASTIAN; EISENBERG BORIS; HARPE CAROLIN 权利人:ROHMAX ADDITIVES GMBH 摘要:The present invention relates to a process for synthesis of polymer compositions with reduced catalyst content, wherein ethylenically unsaturated monomers containing less than 0.5 wt % of ethylenically unsaturated monomers with at least one carboxylic group, sulfonic acid group and/or at least one phosphonic acid group relative to the total weight of the ethylenically unsaturated monomers are polymerized by means of initiators containing a transferable group of atoms and of one or more catalysts comprising at least one transition metal in the presence of ligands which can form a coordination compound with the metal catalyst or catalysts and, after the polymerization, the catalyst contained in the polymer is at least partly separated. For this purpose, the polymer composition is filtered, after the polymerization, in the presence of at least one filter aid which contains at least 0.5 wt %, relative to the total weight of the filter aid, of repeating units that contain at least one carboxylic acid group, sulfonic acid group and/or at least one phosphonic acid group.
[参考文献]: Arun Kumar, Et Al. Rop And Atrp Fabricated Dual Targeted Redox Sensitive Polymersomes Based On Ppegma-Pcl-Ss-Pcl-Ppegma Triblock Copolymers For Breast Cancer Therapeutics. Acs Appl Mater Interfaces. 2015 May 6;7(17):9211-27. [参考文献]: Ben Newland, Et Al. Magnetically Controllable Polymer Nanotubes From A Cyclized Crosslinker For Site-Specific Delivery Of Doxorubicin. Sci Rep. 2015 Dec 1:5:17478. [参考文献]: Chunlin He, Et Al. Photopatterning Of Cross-Linkable Epoxide-Functionalized Block Copolymers And Dual-Tone Nanostructure Development For Fabrication Across The Nano- And Microscales. Small. 2015 May;11(20):2407-16. [参考文献]: Huai-Song Wang, Et Al. Biocompatible Chiral Monolithic Stationary Phase Synthesized Via Atom Transfer Radical Polymerization For High Performance Liquid Chromatographic Analysis. J Chromatogr A. 2015 Aug 28:1409:132-7. [参考文献]: Iza Denis, Et Al. Histone Deacetylase Inhibitor-Polymer Conjugate Nanoparticles For Acid-Responsive Drug Delivery. Eur J Med Chem. 2015 May 5:95:369-76.
合成参考文献
摘要:Zaidlewicz, M.; Krzemiński, M. P.; Dzieleńdziak, A., Science of Synthesis, (2009) 48, 371. 摘要:Aguilar, E.; López, L. A., Science of Synthesis Knowledge Updates, (2014) 2, 52. 摘要:Lete, E.; Sotomayor, N., Science of Synthesis Knowledge Updates, (2011) 4, 197. 摘要:Marschner, C., Science of Synthesis Knowledge Updates, (2022) 3, 129. 摘要:Degennaro, L.; Perna, F. M.; Florio, S., Science of Synthesis Knowledge Updates, (2012) 1, 193.