CAS: 571188-59-5; Tert-Butyl 4-(6-Aminopyridin-3-yl)Piperazine-1-Carboxylate

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CAS号571189-16-7 4-(6-硝基-3-吡啶基)-... | CAS号39856-50-3 5-溴-2-硝基吡啶 | CAS号775288-71-6 1-(6-硝基吡啶-3-基)哌嗪 | CAS号57260-71-6 1-B°C-哌嗪 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号21717-96-4 2-氨基-5-氟吡啶 | CAS号779345-37-8 5-氟-2-硝基吡啶 | CAS号733038-80-7 4-[6-[[5-溴-4-(环... | CAS号571188-82-4 4-[6-[(6-溴-8-环戊... | CAS号571189-03-2 2-((5-(4-(叔丁氧基羰...

1-(6-硝基吡啶-3-基)哌嗪置于镍 氢气,碳酸氢钠体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应 8.0H,反应生成 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯
参考文献:发现一种有效且选择性的细胞周期蛋白依赖性激酶4/6抑制剂.
标题:发现一种有效且选择性的细胞周期蛋白依赖性激酶4/6抑制剂.
摘要:使用高度选择性的小分子抑制剂抑制细胞周期蛋白依赖性激酶4和6(cdk4 / 6)的药理方法有可能为临床提供新的癌症治疗方法.与其他atp依赖激酶相比,实现对cdk4 / 6的高选择性是一个巨大的挑战.吡啶并[2,3-D]嘧啶-7-模板为抑制宽范围的激酶(包括cdks)提供了有效的平台.现在证明,将吡啶并[2,3-D]嘧啶-7-修饰为在c2-位置包括2-氨基吡啶侧链,为抑制剂在体外对cdk4 / 6提供了出色的选择性.在细胞中,最有选择性的抑制剂以高达细胞增殖ic(50)的100倍的浓度产生g(1)阻滞的细胞,概括了这种选择性特征.
DOI:10.1021/jm049354H

专利信息

专利号:US-10807978-B2
优先权日:2016-07-04
标题:Process for preparation of palbociclib
发明人：MURUGAN ANDIAPPAN; KABRA VIPINKUMAR SHRIRAM; GADE CHINNA SAIDA REDDY; GONDU RAMA RAO; CHANDRASHEKAR SHRAVANKUMAR; PASUPATHY KRISHNAMOORTHY; KALAISELVAN ANANDAN
权利人:Dr Reddys Laboratories Ltd
摘要:The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2 m 2 /g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m 2 /g.

专利号:US-7781583-B2
优先权日:2006-09-08
标题:Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones
发明人：ERDMAN DAVID THOMAS; FLAMME CATHLIN MARIE; NELSON JADE DOUGLAS
权利人:PFIZER
摘要:The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), n nuseful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof.

专利号:US-10336763-B1
优先权日:2018-05-17
标题:Crystal form B of ribociclib succinate
发明人：KAMANI SATYANARAYANA; LU TZU-CHIANG; CHANG HSIN-YUN; MAI CHIN-CHENG
权利人:CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:The present invention relates to crystal forms B, C and D of Ribociclib succinate salt and derivatives thereof, and their preparation method and composition. The crystal forms B, C and D of Ribociclib succinate salts are obtained by adding 7-cyclopentyl-N,N-dimethyl-2-(5-(piperain-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide solution into succinic acid solution for reaction, stirring the solution under high temperature, filtering the solution after cooling off.

专利号:US-2008125588-A1
优先权日:2006-09-08
标 题:SYNTHESIS OF 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3-d] PRYIMIDIN-7-ONES

专利号:KR-20090052385-A
优先权日:2006-09-08
标题:Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones

专利号:WO-2008032157-A2
优先权日:2006-09-08
标 题:Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones