(3-Chlorophenyl)Magnesium Bromide置于三氟化硼体系中,化学反应生成 3-氯苯硼酸 参考文献:The Dissociation Constants Of The Chlorophenyl And Phenetyl Boric Acids1 标题:The Dissociation Constants Of The Chlorophenyl And Phenetyl Boric Acids1 摘要: DOI:10.1021/ja01319A053
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-8110642-B2 优先权日:2006-05-08 标 题:Synthesis of vinylphenylpyridine and living anionic polymerization 发明人:LEE JAE-SUK; KANG NAM-GOO 权利人:LEE JAE-SUK; KANG NAM-GOO; KWANGJU INST SCI & TECH 摘要:Provided are a vinyl-biphenylpyridine monomer and a polymer thereof. More particularly, the present invention provides a vinyl-biphenylpyridine monomer having a side chain of pyridine or phenylpyridine as a functional group, a homopolymer of which molecular weight and molecular weight distribution are controlled using the monomer, and a block copolymer of which molecular structure and molecular weight are controlled to facilitate synthesis of an organic metal complex. Accordingly, the present invention provides a vinyl-biphenylpyridine monomer and a polymer thereof which are effectively used as nano and optical functional materials.
专利号:EP-1314727-B1 优先权日:2001-11-23 标题 :Direct synthesis of quaternary phenanthridinium salts 发明人:CAPELLE NICOLAS; GALLO ROGER 权利人:MERIAL SAS 摘要:Process for the preparation of phenanthridinium quaternary salts (I) comprises reacting a halo-aromatic compound (II) with a phenyl boronic derivative (III) in a basic medium, in the presence of a palladium catalyst. ?>Process for the preparation of phenanthridinium quaternary salts of formula (I) comprises reacting a halo-aromatic compound of formula (II) with a phenyl boronic derivative of formula (III) in a basic medium, in the presence of a palladium catalyst. ?>R<3>, R<8> = an electro-attractor group having an electronegativity at last equal to that of nitro; ?>R<5> = a non-chemically labile group; ?>R<6> = aryl or 5-12C heteroaryl, which my be condensed and may have one or more hetero atoms; ?>X<-> = a halide or hydrogen sulfate anion or a base joined to a mineral acid; ?>X = halogen; ?>R = H; ?>R+R = a group of formula (i); ?>n, n' = 0-4; ?>R<9>, R<10> = H or 1-5C alkyl. ?>Independent claims are also included for: ?>(1) intermediates of formula (VI); and ?>(2) the preparation of (VI). ?>X1 = halogen.
专利号:US-8106031-B2 优先权日:2006-05-02 标题:Hydrolytically-resistant boron-containing therapeutics and methods of use 发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A 权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC 摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
专利号:US-7968752-B2 优先权日:2003-06-16 标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use 发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A 权利人:ANACOR PHARMACEUTICALS INC 摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
专利号:US-7919618-B2 优先权日:2006-08-04 标 题:Synthesis of piperazines, piperidines and related compounds 发明人:BURGOON JR HUGH ALFRED; KANAMARLAPUDI RAMANAIAH C; WU WENXUE 权利人:LEXICON PHARMACEUTICALS INC 摘要:Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.