CAS: 64248-62-0; 3,4-Difluorobenzonitrile

上下游产品

4-chloro-3-nitrobenzonitrile 3,4-Difluorobenzoic acid 3,4-dichloro-benzonitrile (3,4-difluoro-phenyl)-amide 3-fluoro-4-methoxybenzonitrile 4-dimethylamino-3-fluoro-benzonitrile 4-((2-aminophenyl)thio)-3-fluorobenzonitrile H-4,9-dioxa-2-aza-cyclopenta[b]naphthalene-1,3-dicarboxylic acid dimethyl ester2-benzyl-6-cyano-2H-4,9-dioxa-2-aza-cyclopenta[b]naphthalene-1,3-dicarboxylic acid dimethyl ester

4-氯三氯甲苯置于potassium Fluoride,Ammonium Hydroxide,氯化亚砜,Chlorosulphuric Acid,四苯基溴化膦体系中,用 环丁砜,水,氯苯,甲苯,乙腈,苯 作为反应溶剂,120.0~210.0 °C,36.0 Kpa 条件下,反应 32.0H,反应生成 3,4-二氟苯腈
参考文献:氟化钾交换法通用高效合成间氟芳烃
标题:氟化钾交换法通用高效合成间氟芳烃
摘要:发现四苯基溴化鏻是一种合适的催化剂,用于在化学计量量的邻苯二甲酰氯存在下,使带有氰基,硝基,氯羰基,三氟甲基和氯磺酰基的间硝基芳基衍生物与氟化钾反应,得到相应的间氟芳烃衍生品收益非常好.还发现该催化剂通过使用反应蒸馏技术对间(氟磺酰基)芳基衍生物进行氟脱磺酰化以提供间氟芳烃是有效的.
DOI:10.1246/bcsj.63.2010

专利信息

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-9308194-B2
优先权日:2013-11-28
标 题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：LINGARD IAIN; HAMPRECHT DIETER
权利人:BOEHRINGER INGELHEIM INT
摘要:A compound of formula I, n nwherein the groups R 1 , R 2 , R 3 , X, m, and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:EP-0008532-A1
优先权日:1978-08-22
标 题 :Synthesis of amines

专利号:EP-0040896-A2
优先权日:1978-08-22
标 题 :Synthesis of amides

专利号:CN-104803883-A
优先权日:2015-03-27
标题:Synthesis method of cyhalofop-butyl

专利号:CN-120365188-A
优先权日:2023-12-20
标题:A continuous synthesis process of 3,4-difluorobenzonitrile