CAS: 67442-07-3; 2-Chloro-N-Methoxy-N-Methylacetamide

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CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号79-04-9 氯乙酰氯 | CAS号1634-04-4 甲基叔丁基醚 | CAS号541-88-8 氯乙酸酐 | CAS号584-08-7 碳酸钾 | CAS号1117-97-1 甲氧基甲基胺 | CAS号1104606-44-1 1-(5-氟-2-吡啶基)-2-氯乙酮 | CAS号367508-01-8 (N-甲氧基-N-甲氨基甲酰甲... | CAS号937-38-2 1-氯-3-苯丙-2-酮 | CAS号228710-83-6 2-chloro-1-[6-(... | CAS号191731-32-5 N-methoxy-2-[(4... | CAS号18245-82-4 1-氯-4-三甲基锡-3-丁炔-2-酮 | CAS号78191-00-1 N-甲氧基-N-甲基乙酰胺 | CAS号129986-67-0 N-甲氧基-N-甲基(三苯基膦... | CAS号124931-12-0 (N-甲氧基-N-甲氨基甲酰甲... | CAS号1260759-84-9 1-(5-Bromo-2-py...

氯乙酸,N-甲基-N-甲氧基胺盐酸盐置于三氯化磷体系中,用 甲苯 作为反应溶剂,化学反应 0.67H,以94%的收率获得产物2-氯-正甲氧基-正甲基乙酰胺
参考文献:直接由羧酸直接一锅无过渡金属合成weinreb酰胺
标题:直接由羧酸直接一锅无过渡金属合成weinreb酰胺
摘要:摘要 在一个锅中于60oc在甲苯中以高收率直接由羧酸,N,O-二甲基羟胺和三氯化磷直接制备weinreb酰胺,从而避免了对水分和空气敏感的中间体p [nme(ome)] 3的分离.提前.受位阻的羧酸也以优异的收率获得产物相应的weinreb酰胺.羧酸上具有各种官能团.该方法工艺简单,收率高,适合大规模生产. 在一个锅中于60oc在甲苯中以高收率直接由羧酸,N,O-二甲基羟胺和三氯化磷直接制备weinreb酰胺,从而避免了对水分和空气敏感的中间体p [nme(ome)] 3的分离.提前.受位阻的羧酸也以优异的收率获得产物相应的weinreb酰胺.羧酸上具有各种官能团.该方法工艺简单,收率高,适合大规模生产.
DOI:10.1055/s-0033-1340317

专利信息

专利号:US-5786515-A
优先权日:1995-09-15
标题 :Synthesis of α-chloro or fluoro ketones
发明人：DOLLING ULF H; FREY LISA F; TILLYER RICHARD D; TSCHAEN DAVID M
权利人:MERCK & CO INC
摘要:A simple, high yielding synthesis of a-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.

专利号:WO-2024110994-A1
优先权日:2022-11-25
标题 :A process for the preparation of ledipasvir
发明人：GANGARAJULA SUDHAKAR; CHENNAM RAMU; KUMARAGURU THENKRISHNAN; BABURAO RODE HARIDAS; MADDI REDDY SRIDHAR; CHADA REDDY RAJI; GHOSH SUBHASH
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
摘要:The present disclosure relates to process for the preparation of Ledipasvir (I) or of its pharmaceutically acceptable salts. The present disclosure also provides novel intermediates (IV–XI) that are used in the synthesis of Ledipasvir. The main strategies of the present invention are late-stage functionalization such as difluorination and cyclopropanation of the key intermediates of Ledipasvir (I). (Formula (I))

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

专利号:US-9527877-B2
优先权日:2012-06-29
标题 :Metal complexes, their application and methods of carrying out of metathesis reaction
发明人：SKOWERSKI KRZYSZTOF; BIENIEK MICHAL
权利人:APEIRON SYNTHESIS SA
摘要:This disclosure relates to new metal complexes, such as compounds of Formula 1, and their application in olefin or alkyne metathesis and to methods of carrying out olefin metathesis reactions.

专利号:US-2018351104-A1
优先权日:2012-11-02
标 题:3-substituted tellurophenes and related compounds
发明人：SEFEROS DWIGHT; JAHNKE ASHLEE
权利人:GOVERNING COUNCIL UNIV TORONTO
摘要:Monomeric 3-substituted tellurophene compounds, as well as their use in the synthesis of oligomeric and/or polymeric compounds consisting of two or more tellurophene-2,5-diyl groups which are covalently linked to each other are disclosed, as is the use of said oligomers and polymers in devices such as diodes and solar cells, electrodes and semiconductors.