CAS: 69898-45-9; 4,4'-(3-(Pyridin-2-yl)-1,2,4-Triazine-5,6-Diyl)Dibenzenesulfonic Acid Monosodium Salt

专利信息

专利号:US-2024366804-A1
优先权日:2021-07-30
标题 :Biocompatible imaging particles, their synthesis and use in imaging techniques
发明人：BONNARD THOMAS; JACQMARCQ CHARLÈNE; GAUBERTI MAXIME; MARTINEZ DE LIZARRONDO SARA; VIVIEN DENIS
权利人:INST NAT SANTE RECH MED; UNIV CAEN; CENTRE HOSPITALIER UNIV DE CAEN NORMANDIE
摘要:The present invention relates to novel biocompatible imaging particles comprising superparamagnetic iron oxide (SPIO) assembled into submicromiter-sized clusters within a biodegradable polycathecolamine or polyserotonine matrix, their synthesis and use in imaging techniques. These particles overcome the issues of toxicity and unreliable signal of the molecules from the prior art by providing similar contrast to that of the microparticles of iron oxide and rapidly disassemble into isolated SPIO particles once they reach the acidic lysosomal compartment of the MPS cells, thus enabling their digestion. The present invention is thus directed to a particle having a hydrodynamic diameter comprised between 100 nm and 2000 nm, said particle comprising nanoparticles of iron oxide embedded within a matrix of polycathecolamine or polyserotonine, each of said nanoparticles of iron oxide being coated by a polymer which is different from polycathecolamine or polyserotonine

专利号:US-2024238456-A1
优先权日:2021-07-30
标题 :Self-assembled biocompatible imaging particles, their synthesis and their use in imaging techniques
发明人：GAUBERTI MAXIME; MARTINEZ DE LIZARRONDO SARA; BONNARD THOMAS; JACQMARCQ CHARLÈNE; VIVIEN DENIS
权利人:INST NAT SANTE RECH MED; UNIV CAEN; CENTRE HOSPITALIER UNIV DE CAEN NORMANDIE
摘要:The present invention relates to a biocompatible particle comprising nanoparticles of iron oxide embedded in a polycathecolamine or polyserotonine matrix, a suspension of said particles, a process for preparing said suspension of particles, a conjugate comprising said particle and the use of said particle and said conjugate in imaging techniques.

专利号:US-11078222-B2
优先权日:2016-12-29
标题:Hydroxybenzoic acid derivatives, methods and uses thereof
发明人：MARTINS BORGES MARIA FERNANDA; GOUVEIA SIMÕËS DA SILVA OLIVEIRA PAULO JORGE; SANTOS TEIXEIRA JOSÉ CARLOS; CAGIDE FAGIN FERNANDO; GOMES OLIVEIRA ANA CATARINA
权利人:UNIV DO PORTO; CENTRO DE NEUROCIENCIAS E BIOLOGIA CELULAR
摘要:The present disclosure relates to the design and synthesis of new mitochondriotropic antioxidant compounds based on hydroxybenzoic acids and analogues. Furthermore, this disclosure is also related to the methods and uses of the hydroxybenzoic based derivatives and analogues, for example, in the field of human and animal diseases, for instance to treat mitochondrial dysfunction or mitochondrial deficiencies, and cosmetics, for instance to prevent or delay skin aging.

专利号:CN-115678905-B
优先权日:2021-11-02
标题 :Application of MtCIPK gene in regulation and control of low iron stress resistance and riboflavin synthesis of plants

专利号:US-2011045991-A1
优先权日:2005-06-23
标 题:Methods for the Detection of Colorectal Cancer
发明人：GITE SADANAND; MCCULLOUGH JENNIFER A; ROTHSCHILD KENNETH J
权利人:GITE SADANAND; MCCULLOUGH JENNIFER A; ROTHSCHILD KENNETH J
摘要:This invention relates to an approach for detection of chain truncating mutations based on the utilization of existing sample collection methods such as FOBT platforms, together with advanced methods for cell-free protein expression. “When further combined with mass spectrometry, the invention provides the ability to simultaneously detect changes in the amino acid sequence of multiple peptides. In some embodiments, DNA is isolated from a patient fecal sample and specific regions of a gene (i.e., for example, a K-ras gene or an APC gene) are PCR amplified using specifically designed primers that allow translation of encoded peptide fragments in a cell-free protein synthesis system. Nascent proteins are affinity purified and their mass is detected by MALDI-TOF which allows identifying low levels of mutations.

专利号:CN-115678905-A
优先权日:2021-11-02
标 题 :Application of MtCIPK12 gene in regulation and control of low-iron stress resistance and riboflavin synthesis of plants