CAS: 71-58-9; (6S,8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-Trimethyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-Yl Acetate

上下游产品

CAS号32634-95-0 6-亚甲基孕甾-4-烯-17A... | CAS号809-01-8 Edogestrone | CAS号3386-01-4 6β-Methyl-3,20-... | CAS号3386-00-3 17-hydroxypregn... | CAS号3496-78-4 (5α,6α)-Epoxy-1... | CAS号520-85-4 甲羟孕酮 | CAS号108-24-7 乙酸酐 | CAS号1863-39-4 Pregn-5-en-20-o... | CAS号113665-92-2 3β,5,17-trihydr... | CAS号3562-63-8 甲地孕酮 | CAS号595-33-5 醋酸甲地孕酮 | CAS号520-85-4 甲羟孕酮 | CAS号69688-15-9 [(5S,6S,8R,9S,1...

6-Formil-3-(2'-Chloro-Etossi)-δ3,5-Pregnadien-17α-Ol-20-One Acetato置于palladium On Activated Charcoal 氢气体系中,用 甲醇 作为反应溶剂,化学反应生成 醋酸甲羟孕酮
参考文献:Sciaky,R. Et Al.,Gazzetta Chimica Italiana,1966,Vol. 96,P. 1268-1283
标题:Sciaky,R. Et Al.,Gazzetta Chimica Italiana,1966,Vol. 96,P. 1268-1283

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-10975069-B2
优先权日:2014-04-01
标 题 :Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof
发明人：HAWKINS WILLIAM; MACH ROBERT; SPITZER DIRK; VANGVERAVONG SUWANNA; VAN TINE BRIAN
权利人:UNIV WASHINGTON
摘要:Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described, such as the methanesulfonate salt of a compound of structural Formula IV, n n, wherein n is an integer chosen from 1, 2, 3, 4, and 5, and R 2 is H or methyl. At least one described molecular species exhibits an IC 50 value below 5 μM against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo. It led to a 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.

专利号:WO-2006052263-A1
优先权日:2004-11-10
标题:Synthesis and separation of optically active isomers and cyclopropyl derivatives of spironolactone and their biological action
发明人：RANADE VASANT V; SOMBERG JOHN CHARIN
权利人:RANADE VASANT V
摘要:Methods for separation and synthesis of the optically active 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone are provided. Preferred stereoisomerically purified 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone have fewer effects mediated by gonadal steroid receptors relative to effects mediated by minteralocorticoid progesterone receptors, compared to the stereoisomerically unpurified form of the compound. These optically active compounds can be useful for obtaining reduction in moderate essential hypertension and in the treatment of congestive heart failure in humans with minimized undesirable side effects such as gynecomastia, tender breast enlargement and menstrual irregularities in women, and loss of libido in

专利号:US-2009325918-A1
优先权日:2008-06-16
标 题:Synthesis and separation of optically active isomers and cyclopropyl derivatives of spironolactone and their biological action
发明人：SOMBERG JOHN C; RANADE VASSANT V
权利人:SOMBERG JOHN C; RANADE VASSANT V
摘要:Methods for separation and synthesis of the optically active 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone are provided. Preferred stereoisomerically purified 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone have fewer effects mediated by gonadal steroid receptors relative to effect mediated by minteralocorticoid progesterone receptors, compared to the stereoisomerically unpurified form of the compound. These optically active compounds can be useful for obtaining reduction in moderate essential hypertension and it the treatment of congestive heart failure in humans with minimized undesirable side effects such as gynecomastia, tender breast enlargement and menstrual irregularities in women, and loss of libido in men.

专利号:US-9573873-B2
优先权日:2014-06-03
标题:Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis
发明人：GREEN JAMES; MEHDI MARIAM; DJURDJEVIC SINISA
权利人:UNIV OF WINDSOR
摘要:In a non-limiting embodiment, there is provided a compound of formula (I), which may permit for a method or use in treating or preventing a cancer, such as pancreatic cancer or leukemia. In one embodiment, there is also provide a method of preparing a compound of formula (Ia), the method including conducting a cyclization reaction of a compound of formula (III) to obtain a compound of formula (IV), wherein conducting the cyclization reaction comprises conducting a Michael reaction in the presence of a Lewis acid.