CAS: 96424-68-9; 2-Bromo-3-Chloropyridine

• 英文名称2-Bromo-3-Chloropyridine
• 中文名称2-溴-3-氯吡啶
• IUPAC名称2-bromo-3-chloropyridine
• 其它别名3-氯-2-溴吡啶; 2溴3氯吡啶
• CAS编号96424-68-9
• MFCD编号:MFCD04039344
• EINECS号:678-771-3
• 分子式:C5H3BrClN
• 分子量:192.44
• 产品CID: 2017380
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• InChIKey: GOHBBINNYAWQGO-UHFFFAOYSA-N
• InChI=1S/C5H3BrClN/c6-5-4(7)2-1-3-8-5/h1-3H…
• 计算化学: 氢键受体数1.0氢键供体数0可旋转键数0

相似化合物

物理性质

• 熔点59°C
• 沸点223.9±20.0 °C at 760 mmHg
• 闪点89.2±21.8 °C
• 密度1.7±0.1 g/cm3
• pKa:-1.49±0.10(预测)
• PSA:12.89
• LogP:2.4975
• 折射率1.581
• 蒸汽压0.1±0.4 mmHg at 25°C
• 溶解性Soluble In Methanol
• 敏感性常温常压下稳定，避免与强氧化剂接触。
• 外观形态白色至几乎白色粉末至晶体
• 储存条件惰性气氛,室温
• 产品应用该化合物用于制备其他有机物质,如4-ARYL-2-氨基丁酸和3-卤素-2-(异丁醇)丙烯基丁酯[2,3-B],或参与替代,结合/氢化和催化反应.

MSDS等安全信息

• GHS象形图
• GHS符号GHS06;
  注释: Skull and crossbones
• 危险类别急性毒性 类别3(吸入)
  急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  急性毒性 类别3(经口)
  急性毒性 类别4(吸入)
  严重眼刺激 类别2A
• 警示词Danger(危险)
• 危险描述H331 |吸入会中毒.
  H312 |皮肤接触有害.
  H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H301 |吞咽会中毒.
  H332 |吸入有害.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
• 危险等级6.1
• UN编号2811.0
• 危险品标志Xi,Xn
• 包装等级Ⅲ
• 安全声明26-36/37/39
• 危险类别码20/21/22-36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 2402-77-9 = 96424-68-9
  反应条件:1.1 Reagents: Bromotrimethylsilane Solvents: Propionitrile; 70 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water
  标题:Silyl-Mediated Halogen/halogen Displacement In Pyridines And Other Heterocycles
  作者:Schlosser,Manfred; Cottet,Fabrice
  参考文献:European Journal Of Organic Chemistry 日期:2002 卷标:(24) 页码:4181-4184]
  
  626-55-1 = 96424-68-9
  反应条件:1.1 Reagents: Piperidine,2,2,6,6-Tetramethyl-,Lithium Salt (1:1) Solvents: Diethyl Ether; 0 °C; 0 °C -> -78 °C1.2 Reagents: Lithium Diisopropylamide; 5 - 10 Min,-78 °C1.3 Reagents: Bromine; -78 °C; -78 °C -> Rt1.4 Solvents: Water; Cooled
  标题:A Study On The Bf3 Directed Lithiation Of 3-Chloro- And 3-Bromopyridine
  作者:Dhau,Jaspreet S.; Singh,Amritpal; Kasetti,Yoganjaneyulu; Bhatia,Sonam; Bharatam,Parsad V.; Et Al
  参考文献:Tetrahedron 日期:2013 卷标:69(48) 页码:10284-10291]
  
  626-60-8 = 96424-68-9
  反应条件:1.1 Reagents: 2-(Dimethylamino)Ethanol,Butyllithium Solvents: Hexane1.2 Reagents: Carbon Tetrabromide Solvents: Tetrahydrofuran1.3 Solvents: Water1.4 Solvents: Dichloromethane
  标题:First Regioselective C-2 Lithiation Of 3- And 4-Chloropyridines
  作者:Choppin,Sabine; Gros,Philippe; Fort,Yves
  参考文献:European Journal Of Organic Chemistry 日期:2001 卷标:(3) 页码:603-606]
  
  2764688-14-2 = 96424-68-9
  反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Acetic Acid; 25 °C; 2 - 3 H,60 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; 0 - 5 °C
  标题:A Process For The Preparation Of Substituted Pyridine Compounds And Intermediates Thereof
  参考文献:World Intellectual Property Organization]
  
  = 96424-68-9 [标题:Reaction Conditions
  标题:Atf6 Inhibitors And Uses Thereof As Therapeutic Agents For Treatment Of Viral Infections,Neurodegenerative Diseases,Vascular Diseases,Or Cancer
  参考文献:World Intellectual Property Organization]
  
  = 96424-68-9 [标题:Reaction Conditions
  标题:Preparation Of 2-(Pyridin-2-Yl)Pyrimidines As Agrochemical Fungicides
  参考文献:World Intellectual Property Organization]
  
  57266-69-0 = 96424-68-9 + 2402-77-9
  反应条件:1.1 Reagents: Dibromomethane,Sodium Bicarbonate,Tert-Butyl Hypochlorite,Oxygen; 20 H,70 °C
  标题:Transition-Metal-Free Decarboxylative Halogenation Of 2-Picolinic Acids With Dihalomethane Under Oxygen Conditions
  作者:Zhang,Xitao; Feng,Xiujuan; Zhang,Haixia; Yamamoto,Yoshinori; Bao,Ming
  参考文献:Green Chemistry 日期:2019 卷标:21(20) 页码:5565-5570]
  
  626-60-8 = 96424-68-9
  反应条件:1.1 Reagents: Dibromomethane,Acetic Acid,Anhydride With Hypofluorous Acid Solvents: Dibromomethane
  标题:Chlorination,Bromination And Oxygenation Of The Pyridine Ring Using Acetyl Hypofluorite Made From Fluorine
  作者:Hebel,David; Rozen,Shlomo
  参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(5) 页码:1123-5]
  
  22841-92-5 = 96424-68-9
  反应条件:1.1 Reagents: Bromine Solvents: Chloroform; 40 °C; 4 H,Reflux; Cooled1.2 Reagents: Sodium Bicarbonate Solvents: Water
  标题:Synthesis Of 2-Bromo-3-Chloropyridine
  作者:Chai,Hui-Fang; Zeng,Xiao-Ping; Teng,Ming-Gang; Duan,Lian
  参考文献:Guangzhou Huagong 日期:2013 卷标:41(17) 页码:51-52]
  
  2402-77-9 = 96424-68-9
  反应条件:1.1 Reagents: Bromotrimethylsilane
  标题:Bromotrimethylsilane
  作者:Martinelli,Michael J.
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001]
  
  = 96424-68-9 [标题:Reaction Conditions
  标题:Utilizing Acetyl Hypofluorite For Chlorination,Bromination,And Etherification Of The Pyridine System
  作者:Hebel,David; Rozen,Shlomo
  参考文献:Journal Of Organic Chemistry 日期:1991 卷标:56(22) 页码:6298-301]
  
  73583-41-2 = 96424-68-9 + 107399-32-6 + 626-60-8
  反应条件:1.1 Reagents: Butyllithium,Ethanol-D Solvents: Tetrahydrofuran
  标题:Homotransmetalation Of 2- Or 4-Bromo-3-Halopyridines With Butyllithium. Mechanism Of The Telesubstitution Of Bromine
  作者:Mallet,M.; Queguiner,G.
  参考文献:Tetrahedron 日期:1986 卷标:42(8) 页码:2253-62

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管