CAS: 997-43-3; Potassium 4-Carboxy-2-Oxobutanoate

专利信息

专利号:US-2005009151-A1
优先权日:2003-07-10
标 题 :Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
发明人：CHASE MATTHEW; CLAYTON ROBERT; LANDIS BRYAN; BANERJEE AMIT
权利人:PHARMACIA CORP
摘要:The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.

专利号:WO-2005005633-A2
优先权日:2003-07-10
标 题 :Methods for the stereoselective synthesis and enantiomeric enrichment of b-amino acids

专利号:EP-1646718-A2
优先权日:2003-07-10
标 题 :Methods for the stereoselective synthesis and enantiomeric enrichment of b-amino acids