专利号:US-5436344-A 优先权日:1990-11-29 标 题:3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones
专利号:US-5608071-A 优先权日:1990-11-29 标题 :Synthesis of 3-bromo-5-chloro-2-alkyl-pyridine derivatives
专利号:US-9487523-B2 优先权日:2012-03-14 标题 :Process for making CGRP receptor antagonists 发明人:BELYK KEVIN M; CLEATOR EDWARD; KUO SHEN-CHUN; MALIGRES PETER EMMANUEL; XIANG BANGPING; YASUDA NOBUYOSHI; YIN JIANGUO 权利人:MERCK SHARP & DOHME 摘要:The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine, utilizing a highly effective spiroacid synthesis.
专利号:CN-114105860-A 优先权日:2021-11-12 标题:Catalytic asymmetric synthesis method and application of chiral oxindole spiro-analogue
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).