CAS: 1420478-88-1; (S)-Benzyl 2-(8-Amino-1-Bromoimidazo[1,5-A]Pyrazin-3-yl)Pyrrolidine-1-Carboxylate

相似化合物

1620675-62-8 1256387-74-2 1778673-20-3

上下游产品

(S)-2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)-1-pyrrolidinecarboxylic acid benzyl ester benzyl (2S)-2-(1-bromo-8-chloro-imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate benzyl (S)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate N-Benzyloxycarbonyl-L-proline 4-{8-amino-3-[(2S)-pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide (S,E)-4-(8-amino-3-(1-(4-(pyrrolidin-1-yl)but-2-enoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide (S)-2-((1-(4-(pyridin-2-ylcarbamoyl)phenyl)-8-amino)imidazole[1,5-a]pyrazin-2-yl)pyrrolidine1-yl-carboxylic acid benzyl ester (S)-4-(3-(1-Acryloylpyrrolidin-2-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

(S)-Benzyloxycarbonyl-Proline Acid Chloride置于ammonium Hydroxide,N-溴代丁二酰亚胺(Nbs),三乙胺,三氯氧磷体系中,用 二氯甲烷,N,N-二甲基甲酰胺,异丙醇 用作溶剂,化学反应生成(2S)-2-(8-氨基-1-溴咪唑并[1,5-A]吡嗪-3-基)-1-吡咯烷羧酸苯甲酯
参考文献: Processes To Produce Acalabrutinib[fr] Processus De Production De L'Acalabrutinib
标题: Processes To Produce Acalabrutinib[fr] Processus De Production De L'Acalabrutinib
摘要:本发明涉及一种用于制备公式iv化合物,公式xi化合物以及阿卡拉布替尼的方法,阿卡拉布替尼是一种新一代布鲁顿酪氨酸激酶(btk)抑制剂.

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:WO-2023168108-A2
优先权日:2022-03-04
标 题 :Synthesis of sulfur(vi) compounds and reagents for same