CAS: 163105-90-6; 2-Methoxy-3-Pyridineboronic Acid

相似化合物

532391-31-4 221006-70-8 854373-97-0

上下游产品

2-methoxypyridine 3-iodo-2-methoxypyridine 3-Bromo-2-methoxypyridine Trimethyl borate 2'-methoxy-[2,3']bipyridinyl-3-ylamine 1-benzyl-3-indol-1-yl-4-(2-methoxy-pyridin-3-yl)-pyrrole-2,5-dione 1-benzyl-3-indol-1-yl-4-(2-oxo-1,2-dihydro-pyridin-3-yl)-pyrrole-2,5-dione H-pyrrol-3-yl)-pyridin-2-yl estertrifluoro-methanesulfonic acid 3-(1-benzyl-4-indol-1-yl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-pyridin-2-yl ester

2-甲氧基吡啶置于lithium Diisopropyl Amide,硼酸三甲酯体系中,用 四氢呋喃,正庚烷,乙基苯 用作溶剂,化学反应 3.0H,以13%的收率获得2-甲氧基吡啶基-3-硼酸
参考文献:New Shelf-Stable Halo-And Alkoxy-Substitutedpyridylboronic Acids And Their Suzuki Cross-Coupling Reactions Toyield Heteroarylpyridines
标题:New Shelf-Stable Halo-And Alkoxy-Substitutedpyridylboronic Acids And Their Suzuki Cross-Coupling Reactions Toyield Heteroarylpyridines
摘要:新合成的稳定的吡啶硼酸具有以下特点:溴锂交换反应随后与三异丙基硼酸酯(tipb)反应,生成了2-氟-5-吡啶硼酸(4),3-溴-5-吡啶硼酸(5)和2-乙氧基-5-吡啶硼酸(6);导向锂化反应后与三甲基硼酸酯(tmb)或tipb反应,得到了2-甲氧基-3-吡啶硼酸(8),3-溴-6-甲氧基-4-吡啶硼酸(11)和3-溴-6-乙氧基-4-吡啶硼酸(12).将吡啶硼酸4,6,8和11与3-溴喹啉进行交叉偶联反应([cs2Co3,Pd(Pph3)2Cl2,1,4-二氧烷,95 oc]),得到吡啶基喹啉衍生物13和15-17,产率为50-77%;5的类似反应由于产物14的进一步原位反应,产率较低.将12与2-溴-5-硝基噻吩进行交叉偶联,得到3-溴-4-(5-硝基-2-噻吩基)-6-乙氧基吡啶(18).
Doi:10.1055/s-2003-39158

专利信息

专利号:US-9988371-B2
优先权日:2014-06-03
标 题:Benzimidazole analogues and related methods
发明人：LI HONG-YU; FRETT BRENDAN; SANTORO MASSIMO; CARLOMAGNO FRANCESCA
权利人:UNIV ARIZONA; UNIV FEDERICO II; UNIV ARIZONA
摘要:The invention relates to compounds of the formula (VIII) wherein the moieties R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.

专利号:US-9951062-B2
优先权日:2012-12-14
标 题 :Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANIPISETTY VENU BABU; TALLURI SURESHKUMAR; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:Compounds according to Formulas I, IA or IB: n nto pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.