CAS: 30529-70-5; 2-Chloro-6-Methylnicotinic Acid

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CAS号38116-61-9 2-羟基-6-甲基烟酸 | CAS号39073-14-8 2-氯-6-甲基烟酸乙酯 | CAS号53277-47-7 4-氯-6-甲基烟酸甲酯 | CAS号65239-37-4 2-(2-methoxyphe... | CAS号65239-42-1 9-methoxy-2-met... | CAS号681161-09-1 6-methyl-2-(4-m... | CAS号889879-45-2 2-(bromomethyl)... | CAS号889879-49-6 7-methoxy-2-met... | CAS号889879-50-9 6-(ethylamino)-... | CAS号889879-69-0 2-(4-methoxycar... | CAS号889879-71-4 2-(4-methoxyphe...

2-羟基-6-甲基烟酸置于三氯氧磷体系中,化学反应生成2-氯-6-甲基烟酸
参考文献:Herbicidal Pyridopyridazinones And Pyridopyridazinethiones
标题:Herbicidal Pyridopyridazinones And Pyridopyridazinethiones
摘要:Pyrido[2,3-D]Pyridazin-5-One和pyrido[2,3-D]Pyridazin-5-Thione的一般式(I)衍生物:其中r和r.Sup.1独立地代表氢,可选择卤代烷基,烯基或炔基,可选择取代的杂环或一个群--[cr.Sup.41 R.Sup.42].Sub.N-(苯基)-(R.Sup.3).Sub.Q;R.Sup.2代表卤素,可选择卤代烷基,烯基或炔基,Cn;--Co.Sub.2R.Sup.4;--S(O).Sub.Rr.Sup.4;--No.Sub.2;--Nr.Sup.41R.Sup.42;--Oh;--Cor.Sup.4,--S(O).Sub.Rr.Sup.5,--Co.Sub.2R.Sup.5,--Or.Sup.5;--Conr.Sup.41R.Sup.42,--Oso.Sub.2R.Sup.5,--Oso.Sub.2R.Sup.6,--och.Sub.2R.Sup.5,--N(R.Sup.41)Cor.Sup.6,--N(R.Sup.41)So.Sub.2R.Sup.5,--N(R.Sup.41)So.Sub.2R.Sup.6,--So.Sub.2Nr.Sup.41R.Sup.42,可选择取代的苯基,烷氧基或卤代烷氧基;X代表氧或硫;R.Sup.3代表卤素,可选择卤代烷基,烯基,烷氧基,炔基,--Oh,--S(O).Sub.Rr.Sup.4,--Co.Sub.2R.Sup.4,Cor.Sup.4,--Cn,--No.Sub.2,--Nr.Sup.41R.Sup.42,--Or.Sup.5;--Conr.Sup.41R.Sup.42,--Oso.Sub.2R.Sup.5,--Oso.Sub.2R.Sup.6,--och.Sub.2R.Sup.5,--N(R.Sup.41)Cor.Sup.6,--N(R.Sup.41)So.Sub.2R.Sup.5,--N(R.Sup.41)So.Sub.2R.Sup.6或--So.Sub.2Nr.Sup.41R.Sup.42;R.Sup.4代表氢原子或可选择卤代的c.Sub.1-6烷基;R.Sup.41和r.Sup.42,可以相同也可以不同,每个代表氢原子或可选择卤代的c.Sub.1-4烷基;R.Sup.5代表一个苯基,可选择由卤素,硝基,氰基,R.Sup.4和--Or.Sup.4中选择的一到五个基团取代;M代表零或一个从一到三的整数;N代表零,一或二;当n为二时,群--(Cr.Sup.41R.Sup.42)--可以相同也可以不同;Q代表零或一个从一到五的整数;R代表零,一或二;但是当m代表零时,R和r.Sup.1不同时代表氢;其农业上可接受的盐对除草剂有用.

专利信息

专利号:WO-2023122754-A1
优先权日:2021-12-23
标 题 :Processes and intermediates for preparing gb13, gb22 and himgaline
发明人：LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
权利人:SCRIPPS RESEARCH INST
摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-5712286-A
优先权日:1994-10-06
标 题 :Naphthyridine derivatives
发明人：GILL JULIE CAROLYN; LESLIE BRUCE WILLIAM
权利人:KNOLL AG
摘要:PCT No. PCT/EP95/03769 Sec. 371 Date Mar. 24, 1997 Sec. 102(e) Date Mar. 24, 1997 PCT Filed Sep. 23, 1995 PCT Pub. No. WO96/11198 PCT Pub. Date Apr. 18, 1996Compounds of formula (I) including pharmaceutically acceptable salts thereof in which R1 represents a C1-6 alkyl group; R2 represents a group of the formula COOR4 in which R4 represents a C1-5 alkyl group; and R3 represents a group of formula COOR5 in which R5 represents a C1-5 alkyl group are disclosed, which are anti-rheumatic agents and are useful as modulators of cytokine synthesis, immunomodulatory agents, anti-inflammatory agents and anti-allergic agents. Compositions containing these compounds and processes to make these compounds are also disclosed.

专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.