CAS: 4474-86-6; N-Cbz-D-Asparagine

上下游产品

CAS号2058-58-4 D-天冬酰胺一水物 | CAS号501-53-1 氯甲酸苄酯 | CAS号5794-24-1 D-天冬酰胺(一水物) | CAS号29880-22-6 Nα-苄氧羰基-DL-天冬酰胺 | CAS号2058-58-4 D-天冬酰胺一水物 | CAS号62234-37-1 N(α)-Z-D-2,3-二氨基丙酸 | CAS号159002-15-0 2-苄氧基羰基氨基-3-叔丁氧... | CAS号634614-25-8 (R)-3-cbz-2-氧代咪...

Z-Dl-天冬酰胺酸置于辛可宁体系中,化学反应生成 N-苄氧羰基-D-天冬酰胺
参考文献:Berlingozzi Et Al.,Gazzetta Chimica Italiana,1958,Vol. 88,P. 9,12
标题:Berlingozzi Et Al.,Gazzetta Chimica Italiana,1958,Vol. 88,P. 9,12

专利信息

专利号:US-6458822-B2
优先权日:2000-03-13
标题 :2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
发明人：ROBINSON RALPH P; LAIRD ELLEN R
权利人:PFIZER
摘要:The present invention relates to a compound of the formula n wherein R 1 , R 2 , R 3 and R 4 are as defined above, and pharmaceutically acceptable salts and solvates thereof, that are useful, for example, as matrix metalloproteinase inhibitors. The present invention is also directed to pharmaceutical compositions comprising such compounds and methods of treatment for diseases such as osteoarthritis, rheumatoid arthritis, cancer, osteoporosis, tissue ulceration, restinosis, periodontal disease, inflammation, epidermolysis bullosa, scleritis, stroke, Alzheimer's disease, and the like, characterized by inappropriate matrix metalloproteinase activity. Processes for the synthesis of compounds of formula (I) are also disclosed.