CAS: 58530-53-3; 2,4-Dibromopyridine

相似化合物

2408-70-0 109-04-6 626-05-1

上下游产品

CAS号626-03-9 2,4-二羟基吡啶 | CAS号52092-43-0 2-溴-4-硝基吡啶-N-氧化物 | CAS号117196-08-4 2,4-二溴吡啶1-氧化物 | CAS号13534-89-9 2,3-二溴吡啶 | CAS号26452-80-2 2,4-二氯吡啶 | CAS号1206975-33-8 2-chloro-4-(tri... | CAS号7598-35-8 4-氨基-2-溴吡啶 | CAS号14305-17-0 2-溴吡啶-N-氧化物 | CAS号1060805-69-7 1-(4-溴吡啶-2-基)乙酮 | CAS号396092-82-3 2-溴-4-二甲基氨基吡啶 | CAS号942206-14-6 4,6-二溴-2,3-联吡啶 | CAS号942206-16-8 6,2’-二溴-3,4’-联吡啶 | CAS号84249-14-9 2-氨基-4-溴吡啶 | CAS号7598-35-8 4-氨基-2-溴吡啶 | CAS号98420-98-5 4-溴-2-苯基吡啶 | CAS号26274-35-1 2,4-二苯基吡啶 | CAS号54151-74-5 2-溴-4-苯基吡啶 | CAS号59717-96-3 5-溴-2-苯氧基吡啶

2,4-二氯吡啶置于三甲基溴硅烷体系中,用 Various Solvent(S) 作为反应溶剂,以49%的收率获得产物2,4-二溴吡啶
参考文献:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
标题:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
摘要:用溴三甲基硅烷加热将 2-氯吡啶转化为 2-溴吡啶,将 2-氯-6-甲基吡啶转化为 2-溴-6-甲基吡啶.2-氯吡啶和2-溴吡啶都得到相应的碘化合物.当用原位反应生成的碘三甲基硅烷处理时.尽管 3-和 4-氯吡啶是完全惰性的,但 2,4-二氯吡啶在 2-和 4-位同时进行卤素/卤素交换.卤素置换仅在 2-位与 2,3-二氯吡啶和 2,5-二氯吡啶发生.与作为发生卤素交换的先决条件的 N-三甲基甲硅烷基吡啶鎓盐的中间体一致,2-氟吡啶和 2-氟-6-甲基吡啶和任何 2,6-二卤代吡啶都不发生反应.最后,溴/氯和碘/氯取代也可以用 2-或 4-氯喹啉,1-氯异喹啉,2-氯嘧啶,氯吡嗪和 2,3-二氯喹喔啉作为底物来完成.[在 Scifinder (R) 上]
DOI:10.1002/1099-0690(200212)2002:24<4181::Aid-Ejoc4181>3.0.Co;2-M

专利信息

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:WO-2024022910-A1
优先权日:2022-07-26
标题 :1-[1-[2-(pyrimidin-4-yl)-1,2,4-triazol-3-yl]ethyl]-3-[2,4-dichloro-5-phenyl]urea derivatives and similar compounds as pesticides
发明人：WEISS MATTHIAS; JEANGUENAT ANDRE; KILARU JAGADEESH PRATHAP; MUEHLEBACH MICHEL; SCARBOROUGH CHRISTOPHER CHARLES; STOLLER ANDRé; SUESSE LARS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to compounds of formula (I) wherein: X is O or S; Q is Q a or Q b as pesticides and insecticides. Preferred compounds are e.g. 1-[1-[2-(pyrimidin-4-yl)-1,2,4-triazol-3-yl]ethyl]-3-[2,4-dichloro-5-phenyl]urea derivatives and similar compounds. An exemplary compound is e.g. 1-[(1S)-1-[2-(6-cyanopyrimidin-4-yl) -1,2,4-triazol-3-yllethyll-3-[2,4-dichloro-5-(trifluoromethyl)phenyllurea (example E1; compound P1). The present invention discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof.

专利号:CN-119912427-A
优先权日:2025-01-02
标题 :Synthesis method of 2-bromo-4- (piperidylmethyl) pyridine