CAS: 6099-03-2; 2-Methoxycinnamic Acid

上下游产品

malonic acid ortho-anisaldehyde 2-(2-methoxybenzylidene)malonic acid water o-methoxystyrene 3-Hydroxyamino-3-(2-methoxy-phenyl)-propionic acid -3-(2-methoxyphenyl)propanoic acid3(carboxy-methyl)thio-3-(2-methoxyphenyl)propanoic acid ethyl 3-(2-methoxyphenyl)acrylate

邻甲氧基肉桂酸乙酯置于水,Sodium Hydroxide体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应生成 2-甲氧基肉桂酸
参考文献:新型 3,4-二氢异喹啉-1(2H)-One 基胡椒龙胺类似物的合成,体外细胞毒性和分子对接研究
标题:新型 3,4-二氢异喹啉-1(2H)-One 基胡椒龙胺类似物的合成,体外细胞毒性和分子对接研究
摘要:为了扩大胡椒碱 (Pl)(一种天然抗癌分子)的 Sar 范围,我们设计了一种含有 3,4-二氢异喹啉-1(2 H)-One 和反式肉桂酸的新型杂化分子.该结构基于杂交策略,用于天然支架的杂交.我们通过使用混合酸酐方法将 3,4-二氢异喹啉-1(2 H)-一个核与肉桂酸偶联,合成了 14 个杂化分子.评估了新合成的抑制剂对乳腺癌mcf-7和宫颈癌hela细胞系的细胞活力.此外,还筛选了活性化合物在乳腺癌mda-Mb-231,宫颈癌中的潜力c33A细胞系,前列腺癌du-145,Pc-3和正常vero细胞.从该系列中,观测到化合物10G显着抑制mcf-7细胞生长,Gi 50 < 0.1 μm,同时抑制mda-Mb-231 (Gi 50 = 20 μm) 和c33A (Gi 50 = 3.2 μm) 的生长.虽然抑制剂10I抑制mcf-7乳腺癌细胞生长 Gi 50 = 3.42 μm 以及抑制mda-Mb-231
DOI:10.1002/jhet.4264

专利信息

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-5856107-A
优先权日:1997-02-04
标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
发明人：OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.

专利号:WO-9834113-A1
优先权日:1997-02-04
标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-5786448-A
优先权日:1996-11-07
标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.