CAS: 70059-30-2; N-Cyano-N'-Methyl-N''-[2-[[(4-Methyl-1H-Imidazol-5-yl)Methyl]Thio]Ethyl]Guanidine Hydrochloride

专利信息

专利号:US-5684130-A
优先权日:1995-06-05
标题 :Process for synthesis of organic compounds using magnetic particles
发明人：SUCHOLEIKI IRVING
权利人:SOLID PHASE SCIENCES CORP
摘要:This invention provides a process for the synthesis of a defined chemical entity, i.e., any desired chemical compound, in high yield using a solid support comprising a magnetic particle, in organic solvents. In general, a sequence of chemical synthetic steps are required to prepare the defined chemical entity bound to the particle. The particle comprises a resin bearing a high concentration of substituent pendant functional groups, to which the first reagent employed in the synthetic sequence binds; in subsequent reaction steps further reagents react with the growing chemical intermediate bound to the pendant functional groups until the defined chemical entity is obtained. The particle also comprises smaller paramagnetic or superpara-magnetic particles incorporated within the resin. The magnetic particle therefore responds to imposed magnetic field gradients, permitting ease of manipulation in steps involving removal of organic solvent.

专利号:US-10370409-B2
优先权日:2011-10-25
标题 :Synthesis of libraries of peptide tertiary amides
发明人：KODADEK THOMAS; GAO YU
权利人:SCRIPPS RESEARCH INST
摘要:The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.

专利号:US-5858534-A
优先权日:1995-09-05
标 题:Method of making and using derivatized paramagnetic polymer beads
发明人：SUCHOLEIKI IRVING
权利人:SOLID PHASE SCIENCES CORP
摘要:A solid phase magnetic support having a hydrophilic surface, a method of making the support, and a method of using the support for peptide synthesis are provided. The solid phase magnetic support is synthesized from a starting material which is a magnetic polystyrene polymer bead which has a plurality of polystyrene coated metal oxide particles randomly distributed in a polystyrene matrix having chloromethyl groups. Hydrophilic long chain hydrocarbon spacer arms, such as polyalkylene diamine molecules are coupled with sonication to the chloromethyl groups. Each spacer arm is provided with a terminal amine for linking to a first amino acid. Preferably, the terminal amine on the spacer arm is provided by a low molecular weight linker molecule which can be acid cleaved from the spacer arm. However, the spacer arm may be derivatized and linked to a first amino acid which cannot be acid cleaved from the spacer arm. The inventive support can be used for automated peptide synthesis or as a support for a bound ligand in bioassays. The support is held in place magnetically while the surrounding solution is siphoned off allowing simultaneous separation of the support bound component from the reactants in solution and washing.

专利号:US-5980861-A
优先权日:1996-03-12
标题 :Chelator compositions and methods of synthesis thereof
发明人：HNATOWICH DONALD J; RUSCKOWSKI MARY; MARDIROSSIAN GEORGE; WINNARD JR PAUL; CHANG FENGCHUN
权利人:UNIV MASSACHUSETTS
摘要:Compositions of radiolabeled nucleic acids and methods for synthesis and use thereof are disclosed.

专利号:EP-0658564-B1
优先权日:1986-04-30
标题 :Electroluminescent compounds and intermediates in their synthesis
发明人：MASSEY RICHARD J; POWELL MICHAEL J; MIED PAUL A; POONIAN MOHINDAR S; FENG PETER; CIANA LEOPOLDO DELLA; DRESSICK WALTER J
权利人:IGEN INT INC
摘要:Novel compounds for use in electrochemiluminescent assays and characterised by containing the structure        X - Y - ZwhereinX represents one or more nucleotides which may be the same or different, one or more amino acids which may be the same or different, an antibody, an analyte of interest or an analogue of an analyte of interestY represents a linker group attached to X and Z,andZ represents an electrochemiluminescent moiety, and intermediates employed in their synthesis.

专利号:US-2007212710-A1
优先权日:2005-12-30
标题:Competitive hybridization of dna probes and method of using the same
发明人：MITTMANN MICHAEL P
权利人:AFFYMETRIX INC
摘要:Methods are presented, in accordance for the present invention, for determining the length of a target probe. The methods have the steps of designing a first hybridization probe having a nucleic acid sequence, a portion of which overlaps with the nucleic acid sequence of a second hybridization probe, designing a second hybridization probe having a nucleic acid sequence, a portion of which overlaps with the nucleic acid sequence of the first hybridization probe, designing a target probe having the nucleic acid sequences of both the first and second hybridization probe and affixing the target probe to a solid support, labeling one of the first and second hybridization probes, but not both, and contacting simultaneously the first and second probes to the target probe, and detecting and quantifying the signal intensity ration between the labeled and non-labeled probes, whereby said ration indicating whether the target probe synthesis has reached full length.