CAS: 7468-67-9; 2-Formylbenzonitrile

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CAS号138642-62-3 2-氰基苯硼酸 | CAS号201230-82-2 carbon monoxide | CAS号655-63-0 2-(dibromomethy... | CAS号22115-41-9 2-氰基溴苄 | CAS号2042-37-7 邻溴苯腈 | CAS号643-79-8 邻苯二甲醛 | CAS号529-19-1 邻甲基苯腈 | CAS号557-21-1 氰化锌 | CAS号104830-22-0 (1Z)-1-[(4-meth... | CAS号3839-22-3 2-氰基苯甲酸 | CAS号52670-38-9 2-氨基苯乙炔 | CAS号4152-92-5 2-(氨甲基)苯甲醇 | CAS号4456-77-3 1,3-[2H,4H]-异喹啉二酮 | CAS号6525-45-7 2-氰基苯甲酸乙酯 | CAS号6587-24-2 邻氰基苯甲酸甲酯 | CAS号3297-72-1 1-苯基异喹啉 | CAS号36078-60-1 2-Benzothiazol-... | CAS号5398-11-8 3-苯基苯酞

邻甲基苯腈置于n-溴代丁二酰亚胺(Nbs),Silver Nitrate,过氧化苯甲酰体系中,用 四氯化碳,水,乙腈 作为反应溶剂,化学反应 25.0H,反应生成 2-氰基苯甲醛
参考文献:原位反应生成的邻醌甲基化物与 3-亚甲基异吲哚啉酮的形式 (4+2) 环加成反应选择性合成螺色曼-异吲哚啉酮
标题:原位反应生成的邻醌甲基化物与 3-亚甲基异吲哚啉酮的形式 (4+2) 环加成反应选择性合成螺色曼-异吲哚啉酮
摘要:使用手性磷酸作为有机催化剂,公开了 3-亚甲基异吲哚啉酮和原位反应生成的邻-醌甲基化物底物的形式不对称 (4+2) 环加成.该反应显示出广泛的底物范围,各种取代的环状烯酰胺和邻羟基苯甲醇衍生物构建了一系列含有螺-N,O-杂环的螺色满-异吲哚啉酮,其ee为 56% 至 93% .该策略展示了建立具有两个手性碳中心(包括四取代碳立体中心)的手性螺-N,O-胺系统的巨大潜力.
DOI:10.1002/adsc.202200350

专利信息

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-2015045564-A1
优先权日:2012-01-03
标 题 :Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES
发明人：REDDY SANTHOSH REKULA; PRAGATI KISHORE PRASAD; NAGA KIRAN; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield. Formula I

专利号:US-2019031702-A1
优先权日:2016-03-14
标 题 :Compounds and Methods for the Synthesis of 5-(N-Protected-Tryptaminocarboxyamide)-2'-Deoxyuridine Phosphoramidate for Incorporation into a Nucleic Sequence

专利号:CN-104725174-B
优先权日:2015-02-16
标 题 :A kind of preparation method of metal-free catalyzed direct synthesis of biaryl compound

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:WO-2010115639-A1
优先权日:2009-04-09
标题 :Process for the synthesis of a propargylic alcohol