专利号:WO-2024130393-A1 优先权日:2022-12-21 标 题 :Nanoparticle and method of synthesis thereof 发明人:MOSKOVCHENKO SVITLANA 权利人:MOSKOVCHENKO SVITLANA 摘要:The present technology relates to nanoparticles, compositions comprising said nanoparticles, and methods of synthesis of said nanoparticles; wherein the nanoparticles comprise a metal nanoparticle core, a first coating of amphiphilic molecules, and a second coating of essential oil, essential oil primary constituent, or both, which combine the antimicrobial properties of metal nanoparticles, amphiphilic molecules, and essential oil or essential oil primary constituents.
专利号:US-9149659-B2 优先权日:2012-11-14 标题 :Cosmetic composition for increasing hyaluronic acid synthesis in skin and its use for repairing wrinkles 发明人:PUJOS MURIEL; BERNINI DOROTHEE; ROBERT CECILE; DOUCET OLIVIER 权利人:COTY GERMANY GMBH 摘要:The present invention relates to a skin composition which has an excellent effect on smoothing or repairing wrinkles. The composition comprises Palmitoyl Tripeptide-38 (Palmitoyl-Lysyl-Dioxymethionyl-Lysine) and Piper nigrum (Pepper) seed Extract which combination has been found to result in a synergistic effect on hyaluronan synthase 1 (HAS1) mRNA expression in human fibroblasts. The hyaluronan synthase is responsible for the synthesis of hyaluronan (hyaluronic acid) in skin. Hyaluronic acid is a constituent of the extracellular matrix of the skin and responsible for space filling, tissue repair and retention of moisture.
专利号:US-2024409571-A1 优先权日:2023-06-08 标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines 发明人:CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN 权利人:UNIV CALIFORNIA 摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.
专利号:US-11116810-B2 优先权日:2012-10-26 标 题 :Methods for treatment of skin and skin appendages with a linseed extract as an active agent activating the synthesis of antimicrobial peptides 发明人:BOTTO JEAN-MARIE; DOMLOGE NOUHA; PORTOLAN FREDERIQUE 权利人:ISP INVESTMENTS INC; ISP INVESTMENTS LLC 摘要:Methods for the treatment of irritations of the skin and skin appendages caused by microbial stresses are disclosed. The methods include providing a composition comprising a linseed extract, obtained from hydrolysis of linseed proteins, as an active antimicrobial agent in a physiologically acceptable medium, and topically applying the linseed extract onto the skin in need thereof. The methods may be useful in the cosmetic and pharmaceutical field and, more particularly, in the field of dermatology. Cosmetic methods for reinforcing the chemical barrier function of healthy and/or sensitive skin and skin appendages are also disclosed that include the same or similar composition and steps.
专利号:US-8067204-B2 优先权日:2005-12-15 标 题 :Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin 发明人:SUGIURA NOBUO; SHIMOKATA SATOSHI; KIMATA KOJI 权利人:SUGIURA NOBUO; SHIMOKATA SATOSHI; KIMATA KOJI; SEIKAGAKU KOGYO CO LTD 摘要:A method for producing a chondroitin sugar chain comprises reacting a glucuronic acid donor, an N-acetyl galactosamine donor, a sugar receptor and a bacterial cell enzyme which synthesizes chondroitin in the presence of a surfactant. The surfactant is selected from polyoxyethylene octadecyl amine, n-decanoyl-N-methylglucamide, sodium cholate, n-octyl-β-D-thioglucopyranoside, n-nonyl-β-D-thiomaltopyranoside, sucrose monocholate, sucrose monocaprate, and sucrose monolaurate. The chondroitin sugar chain has all the following properties: a weight average molecular weight: 50,000 or more when measured by gel filtration chromatography; it is completely degraded to disaccharides with chondroitinase ABC; and when the sugar chain is decomposed with chondroitinase ABC and the decomposed products are subjected to a disaccharide analysis, substantially all of them correspond to an unsaturated disaccharide unit of chondroitin.
专利号:US-9572768-B2 优先权日:2011-04-20 标 题:Cosmetic composition for use in increasing the collagen synthesis in skin cells 发明人:DOUCET OLIVIER; PUJOS MURIEL; ROBERT CÉCILE; BERNINI DOROTHÉE 权利人:DOUCET OLIVIER; PUJOS MURIEL; ROBERT CÉCILE; BERNINI DOROTHÉE; COTY GERMANY GMBH 摘要:The invention refers to a cosmetic composition for increasing collagen synthesis in skin cells comprising 0.001-0.5 wt % of a Phaeodactylum tricornutum extract, 0.00001-2.0 wt % of Dimer Tripeptide-43 or Hydrolyzed Rice Protein, and cosmetic auxiliaries. The cosmetic composition comprising the combination of both components has an synergistic effect on collagen I synthesis in skin cells and has a booster effect to other substances which are known to have an enhancing effect to collagen I synthesis.
[参考文献]: Chuanyu Yang, Et Al. Antimicrobial Nanoemulsion Formulation With Improved Penetration Of Foliar Spray Through Citrus Leaf Cuticles To Control Citrus Huanglongbing. Plos One. 2015 Jul 24;10(7):E0133826. [参考文献]: J Sykora, Et Al. The Effect Of Detergents On Trimeric G-Protein Activity In Isolated Plasma Membranes From Rat Brain Cortex: Correlation With Studies Of Dph And Laurdan Fluorescence. Biochim Biophys Acta. 2009 Feb;1788(2):324-32. [参考文献]: Mika Kaakinen, Et Al. Microdomains Of Endoplasmic Reticulum Within The Sarcoplasmic Reticulum Of Skeletal Myofibers. Exp Cell Res. 2008 Jan 15;314(2):237-45. [参考文献]: S M Jazwinski, Et Al. Preparation Of Extracts From Yeast. Methods Enzymol. 1990:182:154-74. [参考文献]: Sayan Gupta, Et Al. Dna And Protein Footprinting Analysis Of The Modulation Of Dna Binding By The N-Terminal Domain Of The Saccharomyces Cerevisiae Tata Binding Protein. Biochemistry. 2007 Sep 4;46(35):9886-98.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 31(Suppl. 2):169-244, 2012 摘要:International Journal of Toxicology 18(S2):1-8, 1999 参考文献:10.1007/bf01871168 摘要:Sorenson MM, Reuben JP, Eastwood AB, Orentlicher M, Katz GM. Functional heterogeneity of the sarcoplasmic reticulum within sarcomeres of skinned muscle fibers. The Journal of Membrane Biology. 1980 Feb;53(1):1–17. doi: 10.1007/bf01871168. 参考文献:10.1007/s002329900134 摘要:Patel JR, Sukhareva M, Coronado R, Moss R. Chloride-induced Ca 2+ Release from the Sarcoplasmic Reticulum of Chemically Skinned Rabbit Psoas Fibers and Isolated Vesicles of Terminal Cisternae. Journal of Membrane Biology. 1996 Nov 01;154(1):81–9. doi: 10.1007/s002329900134.