CAS: 10212-20-1; 4-Amino-1-((2R,3R,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidin-2(1H)-One

相似化合物

56632-83-8 95058-81-4 122111-03-9

上下游产品

CAS号10212-13-2 3',5'-DI-O-ACET... | CAS号3736-77-4 2,2'-脱水尿苷 | CAS号351523-07-4 3',5'-di-O-(tet... | CAS号31698-14-3 安西他滨 | CAS号78842-13-4 2'-氟-2'-脱氧鸟苷 | CAS号159414-97-8 N4-乙酰基-2'-氟脱氧胞苷 | CAS号134444-47-6 2-氨基-2'-氟-2'-脱氧腺苷 | CAS号80791-93-1 5-碘-2'-氟-脱氧胞苷

2'-氟-2'-脱氧尿苷置于ammonium Hydroxide,二甲基十二/十四烷基叔胺,三乙胺,氯磷酸二苯酯体系中,用 1,4-二氧六环,吡啶,甲醇,乙腈 用作溶剂,化学反应 27.83H,反应生成2'-脱氧-2-氟胞苷
参考文献:低聚核糖核苷酸及其2'-脱氧-2'-氟类似物的异核NMR光谱结构比较
标题:低聚核糖核苷酸及其2'-脱氧-2'-氟类似物的异核NMR光谱结构比较
摘要:合成了1-(2'-Deoxy-2'-Fluororibofuranosyl)pyrimidines,并掺入rna寡核苷酸中,得到5'-R [c F Gc F(u F U F C F G)gc F G]-3'( ç ˚f:C的短形式= 2'-脱氧-2'-氟胞苷;ù ˚f:U的短形式= 2'-脱氧-2'-氟尿苷).通过uv,Cd和NMR光谱研究了低聚物,以解决f标记如何取代核糖环中的13 C标记的问题.通过利用19引起的化学位移的改善分散进行了通孔(noe)和键合(标量耦合)实验f作为替代杂核.给出了氟化的与未改性的低聚物的结构比较.事实证明,与主要采用发夹构象的未修饰寡核苷酸相反,氟化寡核苷酸以14:3的平衡存在于发夹和双链体构象之间.此外,氟化的发夹结构采用两个不同的构象,这两个构象的u和c核苷单元的糖构象不同,如19 F-NMR化学位移所检测到的.讨论了2'-Oh基团在rna二级结构中作为稳定元件的作用.
Doi:10.1002/hlca.19970800614

专利信息

专利号:US-9884885-B2
优先权日:2009-05-18
标题:Synthesis of labile base protected-modified deoxy and modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting group, which is significantly faster base labile protecting group, yet significantly more stable than commonly utilized-2-isobutyryl guanosine is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups, including acetyl group from guanine and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of acetyl protecting groups of the natural deoxy and ribonucleosides occurs under substantially reduced time in contact with mild deprotection conditions such as mild bases, secondary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is designed to lead to high purity large scale therapeutic grade oligonucleotide chimeras which consist of fluoro sugar modification in conjunction with deoxy nucleosides, ribonucleosides, modified base and modified sugar nucleosides. This approach is further designed to use acetyl guanine protecting group when other bases are sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides.

专利号:US-8981076-B2
优先权日:2008-11-29
标 题 :Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:This invention relates to synthesis of novel -N-FMOC protected nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-FMOC as nucleoside base protecting group, which is highly base labile protecting group is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of FMOC protecting groups of the natural deoxy and ribonucleosides occurs under very mild deprotection conditions such as mild bases, secondary and tertiary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is further designed to use FMOC protecting group on various base sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides. DNA oligonucleotides containing 3′-end dA at the 3′-terminal will be produced using the FMOC-dA-supports would lead to much reduced M−1 deletion sequences, and thereby high purity.

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-2025197439-A1
优先权日:2022-03-18
标 题:Decarboxylative acetoxylation using mn(ii) or mn(iii) reagent for synthesis of 4'-acetoxy-nucleoside and use thereof for synthesis of corresponding 4'-(dimethoxyphosphoryl)methoxy-nucleotide
发明人：VAGLE KURT EDRIC; BHADURI SAYANTAN; YANG GUOHAN
权利人:DICERNA PHARMACEUTICALS INC
摘要:The present invention relates to the preparation of nucleic acids, nucleosides, nucleotides, and analogues thereof useful as potent and stable RNA interference agents. The present invention provides improved yields and avoids the use of lead tetraacetate for decarboxylative acetylation which decreases the overall cost of production by removing the need for lead remediation and offers a significant reduction in the environmental costs in production.

专利号:US-8912319-B2
优先权日:2010-07-15
标 题 :Synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-B-D-arabinofuranosyluracil (18F-FMAU)
发明人：LI ZIBO; CAI HANCHENG; CONTI PETER S
权利人:LI ZIBO; CAI HANCHENG; CONTI PETER S; UNIV SOUTHERN CALIFORNIA
摘要:The present invention relates to methods of synthesizing 18 F-FMAU. In particular, 18 F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [ 18 F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.

专利号:US-7339051-B2
优先权日:2003-04-28
标题 :Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)
发明人：CROOKE STANLEY T; ECKER DAVID J; SAMPATH RANGARAJAN; FREIER SUSAN M; MASSIRE CHRISTIAN; HOFSTADLER STEVEN A; LOWERY KRISTIN SANNES; SWAYZE ERIC E; BAKER BRENDA F; BENNETT C FRANK
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.