CAS: 1099-45-2; Ethyl 2-(Triphenylphosphoranylidene)Acetate

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2136-75-6 2605-67-6 5717-37-3

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CAS号105-36-2 溴乙酸乙酯 | CAS号603-35-0 三苯基膦 | CAS号1530-45-6 (乙氧基羰基甲基)三苯基溴化膦 | CAS号637-88-7 1,4-环己二酮 | CAS号17577-28-5 (乙氧基羰基甲基)三苯基氯化膦 | CAS号623-73-4 重氮乙酸乙酯 | CAS号110-44-1 山梨酸 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号140-10-3 肉桂酸 | CAS号101466-85-7 3-(4-(三氟甲基)苯基)丙烯酸乙酯 | CAS号110189-66-7 (1-ethoxy-1-oxo... | CAS号107408-34-4 ethyl 6-chloroh... | CAS号2960-65-8 ethyl 4,4-dieth... | CAS号10602-40-1 2-Butenoic acid... | CAS号5396-71-4 3-硝基肉桂酸乙酯 | CAS号33467-79-7 2,4-庚二烯-1-醇 | CAS号70979-88-3 2E, 4Z Heptadie... | CAS号4046-02-0 阿魏酸乙酯 | CAS号40110-55-2 (1-苄基-哌啶-4-亚丙基)-乙酸乙酯

乙氧甲酰基甲基三苯基溴化膦置于sodium Hydroxide体系中,用 水,甲苯 用作溶剂,化学反应 4.0H,以99%的收率获得乙氧甲酰基亚甲基三苯基膦
参考文献:顺序碱基促进的形式 [4+2] 烯丙酸酯基环加成:功能化吖啶的合成
标题:顺序碱基促进的形式 [4+2] 烯丙酸酯基环加成:功能化吖啶的合成
摘要:( Z )-2-(2-羟基-2-烷基乙烯基)Quinoline-3-Carbaldehydes 和 Allenoates在碱促进的形式 [4+2] 环加成反应中的顺序迈克尔加成,醛醇缩合和异构化过程提供了一种有效的在温和条件下产生官能化吖啶的方法.
Doi:10.1002/ejoc.202200830

专利信息

专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人：HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

专利号:US-9233943-B2
优先权日:2012-01-10
标题:Process for synthesis of syn azido epdxide and its use as intermediate for the synthesis of amprenavir and saquinavir
发明人：GADAKH SUNITA KHANDERAO; REKULA REDDY SANTHOSH; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:A novel synthetic route to the syn-azido epoxide of formula 5 includes cobalt-catalyzed hydrolytic kinetic resolution of a racemic mixture of the azido-epoxide. Reaction steps include subjecting an allylic alcohol to epoxidation with mCPBA to obtain a racemic epoxy alcohol; ring opening the epoxy alcohol with azide anion to obtain an anti-azido alcohol, which can then be selectively tosylated at the primary alcohol; treating the tosylate with base to obtain the racemic azido-epoxide; and subjecting the racemic azido-epoxide to cobalt-catalyzed hydrolytic kinetic resolution to obtain the syn-azido epoxide of formula 5. The compound of formula 5 may be used as a common intermediate for the asymmetric synthesis of HIV protease inhibitors, such as Amprenavir, Fosamprenavir, Saquinavir, and formal synthesis of Darunavir and Palinavir.

专利号:US-2018297925-A1
优先权日:2015-10-12
标题 :Methods for total synthesis of resolvin e1
发明人：JAGTAP PRAKASH
权利人:SALZMAN LOVELACE INVEST LTD
摘要:Methods for total chemical synthesis of Resolvin E1 (RvE1) include Wittig reaction of two compounds having hydroxyl protecting group in the presence of a strong base, removal of the hydroxyl-protecting groups with a deprotecting reagent to produce a compound having an ester group, and hydrolysis of the ester group to obtain RvE1

专利号:US-6849743-B2
优先权日:1997-08-15
标 题 :Synthesis of clasto-lactacystin β-lactone and analogs thereof
发明人：SOUCY FRANCOIS; FLAMONDON LOUIS; BEHNKE MARK; ROUSH WILLIAM
权利人:MILLENNIUM PHARM INC
摘要:The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

专利号:US-9809566-B2
优先权日:2012-09-06
标题:Organocatalytic process for asymmetric synthesis of decanolides
发明人：RAWAT VARUN; DEY SOUMEN; SHELKE ANIL MARUTI; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

专利号:US-8314090-B2
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives
发明人：HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON
权利人:HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON; VENTIRX PHARMACEUTICALS INC; ARRAY BIOPHARMA INC
摘要:The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.