CAS: 1194-16-7; 2,2-Dimethyltetrahydropyran-4-One

该化合物是圆形酮,其特点是稳定的氧气环状结构,在2位置有2个甲基组,该化合物具有有机合成中间体的效用,特别是在生产三环化合物和芳香方面,其僵硬分子框架在选择性变异中加强了反应控制,而氯酮功能允许进一步衍生.化合物在普通有机溶剂中表现出中等溶性,便于在各种反应条件下使用.其结构特征使它适合需要精确的空气和电子调制的应用,如制药和口味化学.

结构式图片

相似化合物

1677677-89-2 1821794-32-4 1197-66-6

欧盟法规

C&L通报

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合成工艺路线路线简述

  • 合成目标产物 2,2-Dimethyltetrahydropyran-4-One 主要起始原料 4H-Pyran-4-One, 2,3-Dihydro-2,2-Dimethyl- And 2H-Pyran-4-Ol, 4-[3-Fluoro-5-(2-Naphthalenyloxy)Phenyl]Tetrahydro-2,2-Dimethyl-
  • (文献来源)合成步骤主要原料 4H-Pyran-4-One, 2,3-Dihydro-2,2-Dimethyl- 和 2H-Pyran-4-Ol, 4-[3-Fluoro-5-(2-Naphthalenyloxy)Phenyl]Tetrahydro-2,2-Dimethyl-
1-羟基-5-甲基-己-4-烯-3-酮置于硫酸体系中,化学反应生成四氢-2 2-二甲基-4H-吡喃-4-酮
参考文献:Nasarow Et Al.,Zhurnal Obshchei Khimii,1957,Vol. 27,P. 1818,1825; Engl. Ausg. S. 1884,1889,1890
标题:Nasarow Et Al.,Zhurnal Obshchei Khimii,1957,Vol. 27,P. 1818,1825; Engl. Ausg. S. 1884,1889,1890

海关参考信息

专利信息


专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人:OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-2019308969-A1
优先权日:2016-11-11
标 题 :Heterocyclic modulators of lipid synthesis

专利号:US-2022296605-A1
优先权日:2011-03-08
标 题 :Heterocyclic modulators of lipid synthesis
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合成参考文献


参考文献:10.1134/s1234567825601330
摘要:Galstyan MV, Harutyunyan AD, Gevorkyan KA, Aleksanyan MV, Nazaryan IM, Paronikyan RG, Gasparyan SP. Synthesis and Neurotropic Activity of Cyclic and Spirocyclic Derivatives of 1,3-Diazadamantane. Russ J Org Chem. 2025 May;61(5):864–71. doi: 10.1134/s1234567825601330.
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