Homofarnesol置于硫酸体系中,化学反应 0.5H,反应生成 十二氢-3A,6,6,9A-四甲基-萘并[2,1-B]-呋喃 参考文献:Process For The Preparation Of (3E,7E)-Homofarnesol 标题:Process For The Preparation Of (3E,7E)-Homofarnesol 摘要:本发明涉及一种改进的制备同方萜醇的新型工艺,特别是(3E,7E)-同方萜醇和含有增加量(3E,7E)-同方萜醇的同方萜醇制备方法(也称为全e-同方萜醇).
专利号:US-4451392-A 优先权日:1982-09-30 标题:Synthesis of triconjugated dienones and novel intermediates used in said process 发明人：EVERS WILLIAM J; STORK GILBERT; MOOKHERJEE BARJA D; HEINSOHN JR HOWARD H 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described is a process for preparing triconjugated dienones defined according to the structure: wherein R1 represents C1-C8 alkyl, phenyl or phenyl methyl and wherein R2 represents hydrogen or C1-C5 lower alkyl; and wherein the wavy lines are indicative of a 'cis' or a 'trans' juxtaposition of the R2, methyl, acyl or vinyl moieties about one or both of the carbon-carbon double bonds which process involves the reaction of an acyl halide having the structure: (wherein X represents chloro) with a substituted or unsubstituted prenyl ester having the structure: wherein R3 represents C1-C5 alkyl in the presence of an aluminum chloride catalyst and a methylene dichloride solvent in order to form the novel intermediate genus defined according to the structure: then dehydrohalogenating the compound defined according to the structure: using an alkali metal carbonate and a dimethylformamide solvent in order to form the novel compound genus having the structure: wherein one of the dashed lines represents a carbon-carbon double bond and the other of the dashed lines represents a carbon-carbon single bond; and then dehydroacyloxylating the compound having the structure: in order to form the compound having the structure: the dehydroacyloxylation step taking place in the presence of an alkali metal carbonate and dimethylformamide solvent.
专利号:US-4560791-A 优先权日:1982-09-30 标题:Synthesis of triconjugated dienones and intermediates used in said process 发明人：EVERS WILLIAM J; STORK GILBERT; MOOKHERJEE BRAJA D; HEINSOHN JR HOWARD H 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described is a process for preparing triconjugated dienones defined according to the structure: wherein R1 represents C1-C8 alkyl, phenyl or phenyl methyl and wherein R2 represents hydrogen or C1-C5 lower alkyl; and wherein the wavy lines are indicative of a 'cis' or a 'trans' juxtaposition of the R2, methyl, acyl or vinyl moieties about one or both of the carbon-carbon double bonds which process involves the reaction of an acyl halide having the structure: (wherein X represents chloro) with a substituted or unsubstituted prenyl ester having the structure: wherein R3 represents C1-C5 alkyl in the presence of an aluminum chloride catalyst and a methylene dichloride solvent in order to form the novel intermediate genus defined according to the structure: then dehydrohalogenating the compound defined according to the structure: using an alkali metal carbonate and a dimethylformamide solvent in order to form the novel compound genus having the structure: wherein one of the dashed lines represents a carbon-carbon double bond and the other of the dashed lines represents a carbon-carbon single bond; and then dehydroacyloxylating the compound having the structure: in order to form the compound having the structure: the dehydroacyloxylation step taking place in the presence of an akali metal carbonate and dimethylformamide solvent.
专利号:US-4467820-A 优先权日:1982-09-30 标题 :Synthesis of triconjugated dienones and novel intermediates used in said process 发明人：EVERS WILLIAM J; STORK GILBERT; MOOKHERJEE BRAJA D; HEINSOHN JR HOWARD H 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described is a process for preparing triconjugated dienones defined according to the structure: wherein R1 represents C1-C8 alkyl, phenyl or phenyl methyl and wherein R2 represents hydrogen or C1-C5 lower alkyl; and wherein the wavy lines are indicative of a 'Cis' or a 'trans' juxtaposition of the R2, methyl, acyl or vinyl moieties about one or both of the carbon-carbon double bonds which process involves the reaction of an acyl halide having the structure: with a substituted or unsubstituted prenyl ester having the structure: wherein R3 represents C1-C5 alkyl in the presence of an aluminum chloride catalyst and a methylene dichloride solvent in order to form the novel intermediate genus defined according to the structure: then dehydrohalogenating the compound defined according to the structure: using an alkali metal carbonate and a dimethylformamide solvent in order to form the novel compound genus having the structure: wherein one of the dashed lines represents a carbon-carbon double bond and the other of the dashed lines represents a carbon-carbon single bond; and then dehydroacyloxylating the compound having the structure: in order to form the compound having the structure: the dehydroacyloxylation step taking place in the presence of an alkali metal carbonate and dimethylformamide solvent.
专利号:US-11214775-B2 优先权日:2018-07-10 标题:Method for biocatalytic production of terpene compounds 发明人：SCHALK MICHEL; ROCCI Letizia; SOLIS ESCALANTE DANIEL 权利人:FIRMENICH & CIE 摘要:Provided herein are biocatalytic methods of producing terpene compounds by applying a novel type of phosphatase enzyme. The method allows the fully biochemical synthesis of terpene compounds, like for example copalol and labdendiol, and derivatives thereof, which serve as valuable intermediates for the production of perfumery ingredients, such as, for example, ambrox. Also provided are novel fully biochemical multistep processes for the production of such compounds as well as novel phosphatase enzymes and mutants and variants derived therefrom.
专利号:US-4560802-A 优先权日:1982-09-30 标 题:Synthesis of triconjugated dienones and novel intermediates used in said process 发明人：EVERS WILLIAM J; STORK GILBERT; MOOKHERJEE BRAJA D; HEINSOHN JR HOWARD H 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described is a process for preparing triconjugated dienones defined according to the structure: wherein R1 represents C1-C8 alkyl, phenyl or phenyl methyl and wherein R2 represents hydrogen or C1-C5 lower alkyl; and wherein the wavy lines are indicative of a 'cis' or a 'trans' juxtaposition of the R2, methyl, acyl or vinyl moieties about one or both of the carbon-carbon double bonds which process involves the reaction of an acyl halide having the structure: (wherein X represents chloro) with a substituted or unsubstituted prenyl ester having the structure: wherein R3 represents C1-C5 alkyl in the presence of an aluminum chloride catalyst and a methylene dichloride solvent in order to form the novel intermediate genus defined according to the structure: then dehydrohalogenating the compound defined according to the structure: using an alkali metal carbonate and a dimethylformamide solvent in order to form the novel compound genus having the structure: wherein one of the dashed lines represents a carbon-carbon double bond and the other of the dashed lines represents a carbon-carbon single bond; and then dehydrocyloxylating the compound having the structure: in order to form the compound having the structure: the dehydroacyloxylation step taking place in the presence of an alkali metal carbonate and dimethylformamide solvent.
专利号:US-4623749-A 优先权日:1982-09-30 标题:Synthesis of triconjugated dienones and novel intermediates used in said process 发明人：EVERS WILLIAM J; STORK GILBERT; MOOKHERJEE BRAJA D; HEINSOHN JR HOWARD H 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described is a process for preparing triconjugated dienones defined according to the structure: wherein R1 represents C1-C8 alkyl, phenyl or phenyl methyl and wherein R2 represents hydrogen or C1-C5 lower alkyl; and wherein the wavy lines are indicative of a 'cis' or a 'trans' juxtaposition of the R2, methyl, acyl or vinyl moieties about one or both of the carbon-carbon double bonds which process involves the reaction of an acyl halide with a substituted or unsubstituted prenyl ester having the structure: wherein R3 represents C1-C5 alkyl in the presence of an aluminum chloride catalyst and a methylene dichloride solvent in order to form a halogen-ester intermediate defined according to the structure: then dehydrohalogenating said halogen-ester intermediate using an alkali metal carbonate and a dimethylformamide solvent in order to form a ketoester having the structure: wherein one of the dashed lines represents a carbon-carbon double bond and the other of the dashed lines represents a carbon-carbon single bond; and then dehydroacyloxylating the ketoester in the presence of an alkali metal carbonate and dimethylformamide solvent in order to form the triconjugated dienone.
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