CAS: 381725-50-4; 1-Phenyl-5-(Pyridin-2-yl)-1,2-Dihydropyridin-2-One

相似化合物

381248-06-2 380918-51-4 1198412-38-2

上下游产品

5-(2-吡啶基)-1,2-二氢吡啶-2-酮 5-(2-Pyridyl)-1,2-Dihydropyridin-2-One 381233-78-9

三正丁基2-吡啶基锌置于吡啶,四(三苯基膦)钯,水,氢溴酸,Copper Diacetate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 22.0H,反应生成1-苯基-5-(吡啶-2-基)吡啶-2(1H)-酮
参考文献:A Practical,Laboratory-Scale Synthesis Of Perampanel
标题:A Practical,Laboratory-Scale Synthesis Of Perampanel
摘要:口服活性,非竞争性,选择性ampa受体拮抗剂perampanel,化学名称为2-[1',6'-二氢-6'-氧基-1-苯基-(2',3'-联吡啶)-5'-基]苯腈,已从易得且相对便宜的原料中制备得到.该合成在实验室规模上进行,无需专用设备,仅涉及两次色谱纯化.
Doi:10.1055/s-0031-1289587

专利信息

专利号:US-10111867-B2
优先权日:2015-02-17
标题:Process and intermediates for the preparation of perampanel
发明人：MAROM EHUD; RUBNOV SHAI
权利人:MAPI PHARMA LTD
摘要:The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-hydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.

专利号:US-9695147-B2
优先权日:2013-07-25
标题 :Process for the preparation of perampanel
发明人：BUCHLOVIC MARIAN
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present invention provides intermediates useful for the synthesis of Perampanel and processes employing said intermediates for preparing Perampanel. The invention also provides processes for making the intermediates, crystalline forms of the intermediates and the use of the crystalline forms for preparing Perampanel.