CAS: 401916-61-8; Mpeg-Sh,Mw:750

专利信息

专利号:WO-2025105584-A1
优先权日:2023-11-15
标 题:Cell-free protein synthesis method using photothermal effect
发明人：KIM DONG-MYUNG; PARK JI HO; YEOM KYUNGHWAN; PARK YU JIN; KIM HANSOL; SONG DONG-YEON
权利人:REPUBLIC OF KOREA DEFENSE ACQUISITION PROGRAM ADMINISTRATION
摘要:The present invention relates to a cell-free protein synthesis method using a photothermal effect, wherein gold nanorods (GNR) having photothermal properties are introduced into a CFPS reaction mixture to induce a rapid and intensive local increase in temperature required for cell-free protein synthesis. The method of the present invention can improve protein yield within a shorter reaction time than a conventional incubation method. By using a PDMS well plat, the method allows for portable and efficient protein synthesis in various environments.

专利号:US-11419952-B2
优先权日:2017-05-19
标 题 :Functionalized nanoparticles and methods of making and using same
发明人：MA KAI; WIESNER ULRICH B
权利人:UNIV CORNELL
摘要:Described is a versatile surface modification approach to, for example, modularly and orthogonally functionalize nanoparticles (NPs) such as, for example, PEGylated nanoparticles, ith various types of different functional ligands (functional groups) on the NP surface. It enables the synthesis of, for example, penta-functional PEGylated nanoparticles integrating a variety of properties into a single NP, e.g., fluorescence detection, specific cell targeting, radioisotope chelating/labeling, ratiometric pH sensing, and drug delivery, while the overall NP size remains, for example, below 10 nm.

专利号:WO-2024163462-A1
优先权日:2023-01-31
标 题:Magnetic hydrogel particles and methods of use
发明人：CHAN ALIX I; CUNNINGHAM CHRISTIAN NATHANIEL; PAEGEL BRIAN; CAVETT VALERIE
权利人:GENENTECH INC; UNIV CALIFORNIA
摘要:The present invention relates to particles comprising a magnetic core coated in a polymeric gel, methods of making such particles, and methods of using such particles, for example to support both chemical and biological synthesis.

专利号:WO-2024163471-A1
优先权日:2023-01-31
标题:Magnetic hydrogel particles and methods of use
发明人：PAEGEL BRIAN; CAVETT VALERIE
权利人:UNIV CALIFORNIA
摘要:The present invention relates to particles comprising a magnetic core coated in a polymeric gel, methods of making such particles, and methods of using such particles, for example to support both chemical and biological synthesis.

专利号:US-2023110994-A1
优先权日:2020-01-03
标题:Conjugates undergoing intramolecular rearrangements
发明人：WEISBROD SAMUEL
权利人:ASCENDIS PHARMA AS
摘要:The present invention relates to conjugates and pharmaceutically acceptable salts thereof, reagents, intermediates, methods for the synthesis of said conjugates, pharmaceutical compositions comprising said conjugates and the use of said conjugates.

专利号:US-11499185-B2
优先权日:2015-07-21
标 题:Nucleic acid sequencing methods and systems
发明人：VIJAYAN KANDASWAMY; TU EUGENE; BERNARD MARK A
权利人:OMNIOME INC; PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:The present disclosure provides compositions, methods and systems for sequencing a template nucleic acid using a polymerase based, nucleic acid binding reaction involving examination of the interaction between a polymerase and template nucleic acid in the presence of one or more unlabeled nucleotides. The methods rely, in part, on identifying a base of a template nucleic acid during nucleic acid synthesis by controlling the sequencing reaction conditions. Template nucleic acid bases may be identified during an examination step followed by an optional incorporation step.