CAS: 5231-87-8; 3,4-Diethoxycyclobut-3-Ene-1,2-Dione

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2892-62-8 61699-62-5 5222-73-1

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CAS号64-17-5 乙醇 | CAS号2892-51-5 方酸 | CAS号122-51-0 原甲酸三乙酯 | CAS号3200-96-2 全氯环丁烯酮 | CAS号109364-34-3 2,3-diethoxy-4-... | CAS号109364-35-4 3-ethoxy-4-(2-t... | CAS号14238-53-0 (4Z)-3-oxo-4-[(... | CAS号19230-34-3 3,4-双二甲基氨基-3-环丁... | CAS号22118-95-2 3-ethoxy-4-phen... | CAS号21647-15-4 3-Cyclobutene-1... | CAS号21647-16-5 3,4-bis(tert-bu... | CAS号29950-12-7 2-氨基-1-乙氧基-3,4-... | CAS号29950-11-6 3-Cyclobutene-1...

2,3-二乙氧基-1,3-丁二烯-1,4-二酮 以 异辛烷 作为反应溶剂,化学反应生成 方酸二乙酯
参考文献:氧取代的双烯酮与环丁烯二酮相互转化的结构效应
标题:氧取代的双烯酮与环丁烯二酮相互转化的结构效应
摘要:Cyclobutenediones 5与ho(二取代的一个),的meo(b),环氧乙烷(ç),我-Pro(d),吨-Buo(ë)的pho(˚f),4-Meoc 6 H ^ 4 O(克),4--O 2 Nc 6 H 4 O(h)和3,4-桥接och 2 CH2O(i)取代基在激光快速光解后得到相应的双烯酮6A-I,通过在2075至2106和2116至2140 Cm-1之间的独特的双重红外吸收来检测.对于6B-E组,回到环丁二烯的开环反应性最大,在25oc下6E(ro = T-Buo)在异辛烷中的速率常数最高,为2.95x10 7 S-1.6A(ro = Oh,K = 2.57x10 6 S-1在ch 3 Cn中),而6F-I的反应性最低,速率常数最低,为3.8x10 4S-1在ch 3 Cn中放置6H(ro = 4-O 2 Nc 6 H 4 O).6F-
DOI:10.1021/jo702312T

专利信息

专利号:US-2024024497-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-8519168-B2
优先权日:2007-07-03
标 题 :Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
发明人：FU XIAOYONG; GUENTER FRANK BRUNO; KIM-MEADE AGNES S; MATTHEWS KENNETH STANLEY; MAUST MATHEW THOMAS; MCALLISTER TIMOTHY L; WERNE GERALD; WINTERS JASON L; YIN JIANGUO; ZHANG SHUYI
权利人:FU XIAOYONG; GUENTER FRANK BRUNO; KIM-MEADE AGNES S; MATTHEWS KENNETH STANLEY; MAUST MATHEW THOMAS; WERNE GERALD; WINTERS JASON L; YIN JIANGUO; ZHANG SHUYI; MOLOZNIK DAVID J; MERCK SHARP & DOHME
摘要:This application discloses a novel process for the preparation of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds, which have utility, for example, in the treatment of CXC chemokine-mediated diseases, and intermediates useful in the synthesis thereof.

专利号:US-7910775-B2
优先权日:2003-04-18
标题 :Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
发明人：YIN JIANGUO; FU XIAOYONG; ZHANG SHUYI; MCALLISTER TIMOTHY L; KIM-MEADE AGNES S; WINTERS JASON L; SUDHAKAR ANANTHA; SCHUMACHER DORIS P
权利人:SCHERING CORP
摘要:Disclosed is a process for making the compound of formula I: n nusing the compounds of formulas II, Q, and XI or XII:n n nwherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C 1 -C 10 )alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:RU-2205834-C2
优先权日:1997-08-01
标题 :Method of synthesis of [2-((8,9)-dioxo-2,6-diazobi-cyclo-[5,2,0]non-1(7)-en-2-yl)ethyl]phosphonic acid, method of synthesis of n-[3-(tertiary butyloxy- carbonylamino)propyl]-2-aminoethylphosphonic acid di-c1-c6-alkyl ester, compounds