CAS: 59337-89-2; 3-Chlorothiophene-2-Carboxylic Acid

上下游产品

3-chlorothiophene-2-carboxaldehyde 2-acetyl-3-chlorothiophene 2,3-Dichlorothiophene 3-chlorothiophene-2-carboxylic acid methyl ester 3-chlorothiophene-2-carboxylic acid methyl ester 3-chloro-4,5-bis(chloromethyl)-2-thiophenecarboxylic acid (3-chloro-2-thienyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone (3-chloro-2-thienyl)(5-hydroxy-1-phenyl-1H-pyrazol-4-yl)methanone

3-氯噻吩-2-甲醛置于氢氧化钾,双氧水体系中,化学反应生成 3-氯噻吩-2-羧酸
参考文献:Profft; Solf,Journal Fur Praktische Chemie (Leipzig 1954),1964,Vol. <4> 24,P. 38,50,64
标题:Profft; Solf,Journal Fur Praktische Chemie (Leipzig 1954),1964,Vol. <4> 24,P. 38,50,64

专利信息

专利号:US-8178672-B2
优先权日:2004-10-19
标 题:Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase
发明人：ASHWELL MARK A; TANDON MANISH; LAPIERRE JEAN-MARC
权利人:ASHWELL MARK A; TANDON MANISH; LAPIERRE JEAN-MARC; ARQULE INC
摘要:An efficient route for the synthesis is of formula (I) of imidazooxazole and imidazothiazole inhibitors of the p38 MAP kinase pathway, useful as therapeutics for disease conditions including inflammation and auto-immune responses is described.

专利号:US-3766236-A
优先权日:1970-11-27
标 题 :Synthesis of halothiolformates
发明人：THALER W; MUELLER W
权利人:EXXON RESEARCH ENGINEERING CO
摘要:HALOTHIOLFORMATES ARE PREPARED BY REACTING A SULFENYL HALIDE WITH CARBON MONOXIDE UNDER MODERATE CONDITIONS OF TEMPERATURE AND PRESSURE, THE PRODUCTS BEING USEFUL AS PESTICIDES AND AS INTERMEDIATES FOR THE PREPARATION OF CARBAMATE PESTICIDES; REACTIVITY OF THE SULFENYL HALIDE MAY BE ENHANCED BY HEAT, POLAR SOLVENTS, AND/OR LEWIS ACID CATALYSTS.

专利号:US-8748459-B2
优先权日:2002-03-29
标 题 :Pyridinoylpiperidines as 5-HT1F agonists
发明人：COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI
权利人:COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI; LILLY CO ELI
摘要:The present invention relates to compounds of formula I: n nor pharmaceutically acceptable acid addition salts thereof, where;n R 1 is C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, substituted C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, substituted C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R 2 is hydrogen, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl-C 1 -C 3 alkyl, or a group of formula II nn n n n n n n n n n n n R 3 is hydrogen or C 1 -C 3 alkyl; n R 4 is hydrogen, halo, or C 1 -C 3 alkyl; n R 5 is hydrogen or C 1 -C 3 alkyl; n R 6 is hydrogen or C 1 -C 6 alkyl; and n n is an integer from 1 to 6 inclusively. n n n n n The compounds of the present invention are useful for activating 5-HT lF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

专利号:US-2009111985-A1
优先权日:2004-10-19
标 题 :Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase

专利号:US-4411838-A
优先权日:1981-01-13
标 题 :Unsymmetrical polynitrocarbonates and symmetrical 1,3-bis(halo- and nitroalkyl carbonyldioxy)-2,2-dinitropropanes and methods of preparation
发明人：GILLIGAN WILLIAM H; STAFFORD SCOTT L
权利人:US NAVY
摘要:Unsymmetrical carbonates of the formula ##STR1## are prepared by the following reaction sequence ##STR2## where R and R' can each be --CH 2 C(NO 2 ) 3 , CH 2 CF(NO..2) 2 , --CH 2 CF 2 (NO 2 ), --CH 2 CCl(NO 2 ) 2 , --CH 2 CF 3 , --CH 2 CCl 3 , --CH 2 C(NO 2 ) 2 CH 3 , or --CH 2 CF 2 CF 2 H, provided that R≠R' and wherein R' is a lower alkyl group of from 1 to 6 carbon atoms. n Also included are symmetrical 1,3-bis(halo- and nitroalkyl carbonyldioxy)-2,2-dinitropropanes of the formula ##STR3## which are synthesis by the following reaction sequence ##STR4## wherein R and R' are as defined above. The carbonates of this invention are useful as energetic additives to propellants and explosive.

专利号:US-4332744-A
优先权日:1981-01-13
标 题:Unsymmetrical polynitrocarbonates and methods of preparation
发明人：GILLIGAN WILLIAM H; STAFFORD SCOTT L
权利人:US NAVY
摘要:Unsymmetrical carbonates of the formula ##STR1## are prepared by the following reaction sequence ##STR2## where R and R' can each be --CH 2 C(NO 2 ) 3 , CH 2 CF(NO..2) 2 , --CH 2 CF 2 (NO 2 ), --CH 2 CCl(NO 2 ) 2 , --CH 2 CF 3 , --CH 2 CCl 3 , --CH 2 C(NO 2 ) 2 CH 3 , or --CH 2 CF 2 CF 2 H, provided that R≠R' and wherein R' is a lower alkyl group of from 1 to 6 carbon atoms. n Also included are symmetrical 1,3-bis(halo- and nitroalkyl carbonyldioxy)-2,2-dinitropropanes of the formula ##STR3## which are synthesis by the following reaction sequence ##STR4## wherein R and R' are as defined above. The carbonates of this invention are useful as energetic additives to propellants and explosive.